This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 57
Epigenetics studies inherited mechanisms capable of modulating gene expression without altering the DNA nucleotide sequence. Until very recently, epigenetics included inherited mechanisms, such as DNA methylation and histone modification. As of today, a large …
One of the ways to restore the lost functions of the thyroid gland is the creation of its tissue engineering constructs. The creation of adequate tissue engineering constructs requires either cultures of functionally active thyrocytes capable of forming thyroi…
The neuropeptide galanin (Gal) is widely distributed as well in central and peripheral nervous system, as in other organs and tissues of humans and animals. Its pleotropic effect is due to an activation or inhibition of galanin specific receptors – GalR1, GalR…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
ntroduction. Agr2protein belongs to the family of disulfide isomerases of the endoplasmic reticulum and contains active cysteine domains involved in the formation of disulfide bonds with mucins. It is expressed in goblet cells of the intestinal epithelium and …
Calbindin 28 kDa, calretinin and parvalbumin are referred to calcium-binding proteins which are both widely distributed in the nervous system and selectively expressed in certain population of neurons. These proteins are expressed not only in the central nervo…
Exosomes are microscopic extracellular vesicles with diametr 30–100 nm, which are secreted by different types of cells and may be detected in normal (blood serum, saliva, urine, breast milk) and pathological (ascite) biological fluids. It was shown that exosom…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
Introduction. The transcriptional activity of hypoxia-inducible factor 1 (HIF1) not only drives cellular adaptation to O2 deficiency, but also plays an important role in the development and functioning of various organs and tissues. Data on the role of HIF reg…
Introduction. Clinical observations have revealed that the treatment of schizophrenia with the use of chlorpromazine (CPZ) impairs cognitive processes. Whether it is possible to eliminate these side effects of CPZ? The aim of the study. The aim of our study wa…
Introduction. Glaucoma is associated with a progressive decrease of visual functions, leading to blindness. One of the important factors is the outflow of the ocular fluid. А genetic association study has identified a sequence variant at the chromosome 7q31 (r…
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
Since the middle of the last century, discoveries in the area of molecular biology and physiology somehow led to the revolution in the view of the function and role of the adipocyte in the human body. To date, there have been known and studied more than four a…
Introduction. Preeclampsia is one of the most frequent complications of pregnancy. Disease is based on the pathology of the vascular system of a pregnant woman. One of the candidate genes of preeclampsia is a gene encoding a protein receptor type 2A to activin…
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…