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Molecular Medicine
Found: 60
Introduction. Determination of the functional activity of the endometrium at the molecular-cellular level opens new perspectives for diagnosis and correction processes of accelerated aging and pathology of the female’s reproductive system. Objective – learning…
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
Introduction. The elevated expression of components of DNA repair system ERCC1 (excision repair cross-complementing group 1) and XPD (Xeroderma pigmentosum group D) is associated with the lack of efficacy of DNA–damaging cytotoxic platinum-based preparations. …
Aim. Lynch Syndrome, which is caused by a defect in one of the mismatch repair (MMR) genes, is the most common among all hereditary colorectal cancer syndromes. Patients with Lynch syndrome in different populations are inherent in both genetic and clinical fea…
Introduction. Despite the fact that portal hypertensive gastropathy (PHG) developing in patients with portal hypertension (PH) is a serious clinical problem, its pathogenesis remains to be poorly studied. The aim of our research was to study the proapoptotic p…
Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…
Introduction. Kisspeptins (KP) are family of peptide mediators regulating function of gonadotrophic axis through the control of secretion of gonadotrophins at the central level. Also was shown that they are synthesized in other tissues and organs, where they h…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
Introduction. Rett syndrome (RTT) is the most common genetic syndrome underlying mental retardation and autism in girls. Etiology of this disorder is related to mutation in the MECP2 gene. However, there are many cases of this disease without the MECP2 mutatio…
Introduction. Diagnosis of genomic and chromosomal anomalies is based on the application of cytogenetic and molecular technologies. The aim of the study. The objective of the work was the delivery and the use of the algorythm for diagnosis of structural genomi…
Genomic and molecular genetic studies of autism can identify new biological markers to determine the etiology and the molecular and cellular mechanisms of the pathogenesis of this disease. In addition to the fundamental importance of this research the laborato…
Introduction. Due to the impetuous development of endovideosurgery in gynecology, laparoscopic access technique is increasingly frequently used to perform myomectomy. However in the available literature until now there is no decisive opinion on the feasibility…
Formation of an effective strategy for managing patients after implantation of an artificial heart valve (АНV), in order to prevent thrombotic complications is an important problem in cardiology. The use of indirect anticoagulants, including warfarin reduces t…
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…
The enhancement of ligand properties of protein molecules treated by toxic reagents has been revealed in model experiments in vitro on ordered protein films. In patients with endogenous intoxication caused by metabolic disorders there were also detected protei…
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the…
The Use of the technique of contrast enhancement in spiral computed tomography (SCT) allows us to study the peculiarities of hemodynamics in the tumor tissue and thus facilitates the differential diagnosis. Сomparison of SKT data with the results of morphologi…
In autoimmune diabetes mellitus (IDDM), clinical manifestation is typically preceded by several years of latent autoimmune insulitis. The autoimmune process arises only in genetically predisposed people,and is usually provoked by an infectious pathogen. Dagnos…
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…