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Molecular Medicine
Found: 109
Introduction. Recent reports have demonstrated patients with malignant neoplasias have different molecular genetic aberrations. But there are few data available concerning patients with multiple primary tumors (MPT). Aim. To study molecular genetic alterations…
Background. Plasminogen activators play the leading role in the tumor growth and metastasis. Growth factors stimulate proliferative processes and are involved in neoangiogenesis. Aim of the study. Identification of changes in components of the fibrinolysis sys…
Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological eff…
Introduction. Among malignant tumors bladder cancer (BC) ranks fifth in the prevalence rate. In the average each year 20% of BC patients die, but in the case of the making diagnosis at the early stages of the disease, survival rate of patients is increasing.Cy…
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
Introduction. Uterine fibroids – a benign tumor, growing from immature muscle cells of the vascular wall of the uterus. It ranked first among the benign tumors of the genital organs, with one in ten suffers from gynecological patients with uterine myoma. The a…
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
On the basis of published data there were assessed criteria of eligibility of paraffin blocks with malignant tumors for the decision of a question of the genetic identity of the samples. In order to prevent potential errors it’s not recommended to use the carc…
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
Introduction. The biologic behaviour of the tumor can be determined by both its own characteristics including ploidity of the tumor cells and peculiarities of its lymphocytic and cytokine microenvironment, in particular. The aim of the study. To perform a comp…
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
Introduction. Insulin-like growth factors (IGF) signaling system plays a major role in the development and progression of various sarcomas and other solid tumors, and therefore its components are regarded as promising diagnostic and prognostic tumor markers an…
Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…