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Molecular Medicine
Found: 559
Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
Introduction. There were examined 195 patients with chronic сerebrovasсular pathology and 149 healthy residents of the Zabaykalsky region. The aim of the study. Detection of genetic polymorphism in cytokines IL4-589С>T, IL10-1082G>A, IL10-819C>T, IL10-592C>A, …
Introduction. Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of GI tract, are characterized by KIT and PDGFRA activating mutations that are predictive factors. KIT and PDGFRA mutations are present in 85% of GISTs and are associated…
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
There is represented immunohistochemical and molecular biological characteristic of some histological types of breast cancer. The assessment of molecular biomarkers in breast cancer has two practical results: identification of risk groups, requiring additional…
The formation of properties promoting malignant transformation begins before the appearance of tumor cells at the level of inflammatory and precancerous processes. The basis for these properties is genomic instability of tumor cells. Genetic instability manife…
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
The lecture considers common concepts of neuroendocrine tumors (NETs). Unlike the other tumors, NETs synthesize a variety of biologically active substances (hormones, peptides, amines), that being their main feature with multiple consequences leads to the deve…
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. DNA methylation is a key epigenetic modification providing the regulation of human genome activity in ontogenesis. DNA methylation patterns were described in the chromosomes from adult lymphocytes. DNA methylation patterns of the chromosomes from…
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. The one of the most important problems of the modern regenerative medicine is incomplete understanding of the influence of mesenchymal stem cells (MSCs) on the growth of malignant neoplasms. Aim of the study. Analysis of the allogeneic MSCs’ effe…
Introduction. Colorectal cancer (CRC) often metastasizes even if the tumor is small in size that is the main cause of death. Complex process of epithelial-mesenchymal transition (EMT) is required for dissemination of tumor cells. EMT leads to the transformatio…