Found: 841
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kurbatova I.V., Dudanova O.P., Topchieva L.V., Larina A.A.
Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., Novikova I.A., Gusareva M.A., Kozhushko M.A.
Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological eff…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Mal'tseva N.V., Laputenko T.A., Gorbatovskii Ya.A.
Introduction. Pathogenesis of infective endocarditis (IE) is not quite clear till now. In last years research of variants of the genes connected with pathogenesis of IE was performed. The aim. The investigation of IE association with gene single-nucleotide pol…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Dusembinova Sh.D., Drobintseva A.O., Sosnina А.К., Zakurina A.N., Polyakova V.O., Pavlova N.G., Kvetnoy I.M.
Introduction. The assessment of placental dysfunction in clinical practice remains to be subject of debates, the search of sustaining morphological markers continues. The aim of the study was to find the correlation between the expression of vimentin and place…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Glukhov A.I., Grigorieva Ya.E., Gordeev S.A., Nalobin D.S., Potoldykova N.V.
Introduction. Among malignant tumors bladder cancer (BC) ranks fifth in the prevalence rate. In the average each year 20% of BC patients die, but in the case of the making diagnosis at the early stages of the disease, survival rate of patients is increasing.Cy…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Mokrushin A.A., Borovikov S.E.
Introduction. We analyzed the hypothesis of cryopreservation of small volumes of nervous tissue (brain slices) without the use of traditional cryoprotectants. The aim of the study. The effects of freezing (-10°C) and rewarming to +37°C examined for changes in …
ОБЗОР2017
Gurova Ya.V., Mordyk A.V.
In the context of the continuing importance of the problem of tuberculosis there must be the selection both of priority areas to combat it, and priority category of patients. The most common form of TB among new cases is infiltrative and successful treatment o…
ОБЗОР2017
Karaulov A.V., Turmova E.P., Markelova E.V., Silaev A.A.
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Vodolazhsky D.I., Dvadnenko K.V., Timoshkina N.N., Abramova N.A., Maksimov A.Yu., Vladimirova L.Yu.
Introduction. Irinotekan is widely used in the treatment of oncological diseases and allows to achieve the objective answer in 35–70% of cases depending on the applied schedule of the treatment. Individual toxicity of a preparation for patients is determined b…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Tatarinova T.N., Alexeyeva N.P., Freylikhman O.A., Kostareva A.A., Grekhov E.V., Moiseeva O.M.
The aim of the study was to establish the contribution of NOTCH1 polymorphisms on the development of a combined bicuspid aortic valve and aortic coarctation. Design and Patients. The study included 34 patients, the control group consisted of 200 cases without …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Bovt P.A., Vishnevskaya T.V., Nurmukhametova E.A., Blokhina N.P., Deryabin P.G., Samokhvalov E.I., Kolobukhina L.V., Khlopova I.N., Kelly E.I., Malyshev N.A., AlkhovskyS.V.
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Elchaninov A.V., Fatkhudinov T.Kh., Usman N.Yu., Makarov A.V., Arutyunyan I.V., Kananykhina E.Yu, Bolshakova G.B., Goldstein D.V., G.T. Sukhikh G.T.
Introduction. Macrophages are referred to the one of the major cell types that organize the liver regeneration. Macrophages are a heterogeneous cell population. The study of regulatory mechanisms of liver regeneration after subtotal liver resection in rats, co…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Surkov A.N., Baranov A.A., Namazova-Baranova L.S., Savostyanov K.V., Pushkov A.A., Zhurkova N.V., Kustova O.V., Potapov A.S., Movsisyan G.B., Gevorkyan A.K., Volynets G.V., Skvortsova T.A.
Introduction. Glycogen storage disease (GSD) type Ib is caused by mutations in the SLC37A4 gene. The aim of the study. To verify the diagnosis by molecular genetic studies. Patient. Child at the age of 5 years and 8 months with severe hepatomegaly, nephromegal…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Ponasenko A.V., Golovkin A.S., Khutornaya M.V., Kutikhin A.G., Yuzhalin A.E., Barbarash O.L., Barbarash L.S.
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Bikbov M.M., Khusnitdinov I.I., Zaydullin I.S., Vildanova R.R., Sigaeva N.N.
Purpose an experimental evaluation of the effectiveness of new hydrogels based on hyaluronic acid and chitosan succinate as an agent of mitomycin C (MMC) for glaucoma surgery. Material and methods. Synthesis of hydrogel drainage (HD): The required amount of MM…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Zuev V.A., Lin’kova N.S., Polyakova V.O., Paltseva E.M., Kvetnaia T.V., Kukanova E.O., . Popuchiev V.V
Introduction. Alzheimer's disease (AD) is a socially important neurodegenerative disease. The prevalence rate of AD is increasing over recent years. According to the hypothesis concerning AD to be a systematic disease its manifestation can be detected in vario…
ОБЗОР2017
Kit O.I., Vodolazhsky D.I., Timoshkina N.N.
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
ОБЗОР2017
Ratushnyak M.G., Severin S.E.
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
ПЕРЕДОВАЯ СТАТЬЯ2017
Zhdanov D.D., Lokhonina A.V., Sokolov N.N.
Telomerase catalytic subunit hTERT is tightly regulated both at the transcriptional and posttranscriptional levels. One of the regulatory mechanisms is its mRNA alternative splicing. Only full-length form has catalytic activity and the ability to elongate telo…
ОБЗОР2017
A.V. Zaborovskiy, N.A. Pyataev, L.A. Tararina, K.G. Gurevich, I.V. Maev, I.S. Кrysanov, D.V. Yunina
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…