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Molecular Medicine
Found: 72
The purpose of this study. Evaluation the effect of Afobazol on the level of myocardial inducible NO-synthase (iNOS) in the ischemic myocardium in rats. Methods. Myocardial ischemia was produced by the Selye’s method. The of inducible NO-synthase level on the …
The purpose of research. The study of the features of the left ventricle remodeling in the acutest stage of experimental myocardial infarction and the possibility of the correction of detected injuries. Methods. Experimental myocardial infarction in rats was i…
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
The aim of the study. The proof of afobazole efficacy for treatment and prevention of alcoholic cardiomyopathy and attendant complications using the previously developed translational model. Materials and methods. Alcoholic cardiomyopathy was produced by conti…
Introduction. The angiogenesis in a uterus scar after application of multipotent mesenchymal stromal cells of a bone marrow origin (MMSCBM) was shown. However, possibility of approach of pregnancy and spontaneous deliveries in rats after MMSCBM introduction in…
The aim of the study – the development of translational models of the alcoholic cardiomyopathy in rats to search and study the action mechanism of new original drugs for the treatment of this pathology. Methods. The complex of echocardiographic, electrophysiol…
Introduction. The one of the most important problems of the modern regenerative medicine is incomplete understanding of the influence of mesenchymal stem cells (MSCs) on the growth of malignant neoplasms. Aim of the study. Analysis of the allogeneic MSCs’ effe…
Introduction. Neuroendocrine cells are involved in multiple regulatory processes. In the article the attention is paid to the key signaling molecules that provide local interactions between neuroendocrine cells after radiation exposure. The aim of the study. T…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
The results of biodistribution of intravenously administrated 188Re-zoledronic acid in rats’ body on the model of bone lesions (callus) are presented. Experiments showed that the complex of 188Re-zoledronic acid has the bone-seeking distribution (up to 31,8% I…
Morphometric studies of the median transverse sections of rat hearts, performed on 28th day after coronary artery ligation, showed that as a result of myocardial infarction the pronounced postinfarction remodelling of the left ventricle of the heart was observ…
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…