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Molecular Medicine
Found: 206
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
Relevance: The review is devoted to the analyses of literature data on disorders of the immune system in COVID-19. Since some of the clinical symptoms of COVID-19 are consistent with those of autoimmune diseases, one of the fundamental questions about COVID-19…
Introduction. Small cell lung cancer (SCLS) is a highly aggressive type of tumor, and various compounds are considered as potential biochemical markers of its prognosis, including neuron-specific enolase (NSE), chromogranin A (CgA), and prograstrin releasing p…
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and m…
Introduction. Prostate cancer (PC) is by far the most commonly diagnosed malignant neoplasm of the urinary system. The pathogenesis and molecular mechanisms of prostate cancer remain incompletely understood. There are reports of the presence in the extracts of…
The reasons for the low efficiency of the α1A-blockers using in the scheme of lithokinetic therapy (LCT) remain unclear. The aim of the study was to evaluate the activity of the purinergic P2X1 receptor in the blockade of the α1A-adrenergic receptor during LCT…
The main reason for the severity of COVID-19 and the death of patients is the «cytokine storm» – a strong inflammatory response caused by SARS-CoV-2. Macrophages, immune cells that help eliminate pathogens and repair damaged tissues, play a key role in the exp…
The majority of IgE binds with Fcε mast cells receptors. Repeated contacts between allergen and specific IgE on the surface of mast cells result in Fcε-receptors cross-linking, degranulation and release of inflammation mediators such as histamine, proteases, c…
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …
The purpose of this review was to describe information about the etiology and pathogenesis of the main manifestations in patients with coronavirus infection COVID-19 and the molecular mechanisms of the possible use of metabolite drugs. Material and methods. Th…
MicroRNAs are defined as short non-coding molecules that regulate gene expression at the post-transcriptional level through complementary binding to the corresponding mRNA. This pairing leads to inhibiting of further translation by mRNA degradation, in other w…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Atopic dermatitis (AD) is characterized by a violation of the epidermal barrier dysfunction. This review examines the work of the authors who describe mutations in the filaggrin gene as predisposing factors for the development of AD and describe the dysfunctio…
Introduction. The human microbiota is part of the «human-microbiome» system and is actively involved in developing various pathological responses and conditions in the body. It is currently essential to study the pathogenesis of ulcerative colitis (UC), a poly…
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…