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Molecular Medicine
Found: 663
Relevance. The mechanisms of B-lymphocyte immunity are not fully understood at present, in particular, the role and significance of the humoral response to viruses. There is insufficient understanding of how B-lymphocytes are selected for differentiation into …
Introduction. This review is devoted to the study of the structure, properties, evolution of hemoglobins, biochemical and clinical aspects of the use of neuroglobin (Ngb) and fetal hemoglobin (HbF) in health and in ischemic hypoxia of the brain. Material and m…
Introduction. The interest in neutrophil extracellular traps (NETs) in various conditions, including pregnancy complications was increased over the last decade. Accompanied by gestational diabetes mellitus (GDM) hyperglycemia contributes to neutrophil’s activa…
Introduction. Bronchial asthma is a heterogeneous disease involving different phenotypes. The allergic phenotype is the most studied model of asthma. Identification of causally significant allergens by determining allergen-specific IgE is the key to precision …
Currently, the diagnosis of early stages of cutaneous T-cell lymphomas (CTCL) is one of the most challenging tasks in dermatology. This review is devoted to the analysis of new immunohistochemical (IHC) markers that could be considered diagnostic for the detec…
Objective. To analyze the current state of preclinical and clinical studies in genome editing for neurodegenerative diseases, evaluate its potential impact on clinical practice, and examine ethical aspects of these technologies’ application. Material and metho…
Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, e…
Introduction. In clinical experiments with various pathologies leading to the activation of POL, it was found that one of the most important areas of correction of oxidative stress is the use of drugs with the properties of antioxidants and antihypoxants [6, 7…
Relevance. The search for new antitumor drugs and their selective delivery directly to the tumor site is an important task of modern oncology. For these purposes, currently, the use of various nanoparticles as carriers of medicinal substances is of great impor…
Objective. To analyze current advances in nanotechnology applications for the development of targeted drugs in oncology, including their mechanisms of action and clinical application prospects. Material and methods. A comprehensive analysis of scientific liter…
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown origin. The study of its features and the development of new diagnostic and treatment methods are limited by the absence of generally accepted experimental models. The purpose of the revi…
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
Introduction. Ionizing radiation can lead to radiation damage to healthy pancreatic tissue, with the development of signs of post-radiation pancreatitis. Electron irradiation potentially has the most “sparing” effect on healthy tissue, but data on this are spa…
Introduction. Alcohol abuse is associated with telomere shortening. There is no convincing evidence of a “safe” level of alcohol consumption in this regard. Long-term studies in rodents are not feasible, and clinical trials with the administration of alcohol t…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
Introduction. Artificial intelligence (AI) technologies are becoming crucial in clinical diagnostics due to their ability to process and interpret large volumes of data. The implementation of AI for biomarker analysis opens new opportunities in personalized me…
Introduction. The study of the effect of peroxynitrite, as a product of nitric oxide (II), on the culture of endothelial cells in vitro can contribute to fundamental ideas about the violation of the adhesive function of the endothelium when changing the synthe…
Introduction. An important pathogenetic link in systemic inflammation in ulcerative colitis (UC) is dysregulation of the immune response. The aim of the study: to study pathogenetic changes in the serum level of interleukin (IL)-4 during UC therapy. Methods. 6…