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Molecular Medicine
Found: 848
Staphylococcus aureus is a common human pathogen. In the past few decades, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become a global problem. MRSA is resistant to all β-lactam antibiotics, except anti-MRSA cephems, and is one…
There are many applications of biosensors in biochemical analysis. High specifity of biorecognizing element that allows to carry out a quantitative analysis of complex analytes with high accuracy and to detect ultrasmall concentration of the certain molecules …
Based on literature data and analysis of own observation the hypothesis of pathogenesis of diffuse parenchymal lung osteodystrophy (DPLOD) is proposed. DPLOD is a very rare disease with unknown etiology. It is characterized by unilateral or bilateral lesions o…
To study the correlation of proliferative activity of tumor cells with clinical and morphological parameters and indices of survival rates a retrospective clinical and morphological analysis of 60 cases of localized and metastatic neuroendocrine tumors (NETs) …
Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and…
Leiomyoma is one of the most common benign tumors of the female reproductive system. As this pathology in most cases is hormone dependent, we determined the level of gene expression of steroid receptors ERs, PR, estrogen sulfotransferase SULT1E1, STS steroid s…
The study data of the epidermal growth factor receptors(EGFR), estrogen and progesterone receptors(ER, PR) in the endometrial tumors in 125 patients are presented. EGFR have been detected in 40% of tumors. The EGFR–RP+ER+ tumors were detected most frequently (…
Argirophilic proteins of nucleolar organizer regions (Ag-NOR) pose a wide group of nucleolar proteins specifically stained by AgNO3. Expression level of Ag-NOR proteins in proliferating cells, including tumor ones, is commonly high. Nucleophosmin/B23 and nucle…
Buccal epithelium (BE) is an easily accessible target for molecular diagnosis of various diseases, and non-invasive way to get it is possible. This review summarizes the results of studies indicating a change in the expression of various signaling molecules an…
An approach to the development of methodology for health risk assessment (HRA) for the effects of new environmental factors: nanoparticles and nanobiomaterials (NP/NBM) – products of modern nano-, nanobiotechnology has been proposed. The experience from develo…
In recent years, scientists from different countries are actively discussing the concept of translational medicine and consider it as important area of molecular medicine development. Translational medicine promotes the transfer of discoveries made in basic bi…
There is a growing body of evidence confirming the validity of the concept of cancer stem cells (CSCs). It is becoming increasingly obvious that CSCs, possessing higher tumorigenicity, metastasis-initiating activity and chemoresistance, are a source of tumor g…
In present study, we investigated the proteasome and calpain activities in patients with endometrial hyperplasia (EH) and endometrial cancer (EC), as well as proteasome subunit composition in EC tissue. EC development was shown to be associated with increased …
The role of aromatase P450 in the pathogenesis of external genital endometriosis (IEG) has been investigated. 45 women with endometriosis have been included in the study, the group of comparison was consisted of 9 healthy women. The examination included a lapa…
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
Sertoli cells are the primary cells that support developing spermatogenic cells in the seminiferous tubules. Heat treatment induces a reversible change in the Sertoli cells (SC) from the mature differentiated state to an immature-like dedifferentiated state. W…
This review is devoted to availability of investigation of expression of signaling molecules in personalized and predictive medicine. As exemplified in cardio-vascular pathology (hypertonic disease, myocardial infarction), Alzheimer’s disease and chronic obstr…
reduced levels of monocytic TF expression in comparison with homozygous ones (160,1±53,0% and 198,6±72,9% M±SD, accordingly). If compared with homozygous allelic variants D-1208I heterozygous genotype is associated with less macrophagic TF expression in lungs …
Microfluidics can raise our sights in the biomedical area. This paper presents an overview of microfluidic systems (IFS), which is evidence of the urgency of this trend. The concept of development of the microfluidic system (MFS) and the technology of producti…
The association of +/– polymorphic markers of GSTM1 and GSTT1 genes and Ile105Val polymorphic marker of GSTP1 gene with the risk of development of breast cancer (BC) and its histological subtypes was studied. We have showed an association of null genotypes of …