This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 848
Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, e…
Introduction. In present, the medical community continues to study the impact of coronavirus infection on various organs and systems of the body. Infection with the SARS-CoV-2 virus causes multifaceted pathological processes and, among other things, affects th…
Introduction. In clinical experiments with various pathologies leading to the activation of POL, it was found that one of the most important areas of correction of oxidative stress is the use of drugs with the properties of antioxidants and antihypoxants [6, 7…
Relevance. The search for new antitumor drugs and their selective delivery directly to the tumor site is an important task of modern oncology. For these purposes, currently, the use of various nanoparticles as carriers of medicinal substances is of great impor…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
Objective. To analyze current advances in nanotechnology applications for the development of targeted drugs in oncology, including their mechanisms of action and clinical application prospects. Material and methods. A comprehensive analysis of scientific liter…
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown origin. The study of its features and the development of new diagnostic and treatment methods are limited by the absence of generally accepted experimental models. The purpose of the revi…
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
Introduction. Ionizing radiation can lead to radiation damage to healthy pancreatic tissue, with the development of signs of post-radiation pancreatitis. Electron irradiation potentially has the most “sparing” effect on healthy tissue, but data on this are spa…
Introduction. One of the actual task of modern biology and medicine. Is the creation of bioregulator preparation, which can stimulate the neuroendocrine system of organism. Purpose of study. Study of effect of polypeptide complex from brain cortex (PPCbc) and …
Introduction. Alcohol abuse is associated with telomere shortening. There is no convincing evidence of a “safe” level of alcohol consumption in this regard. Long-term studies in rodents are not feasible, and clinical trials with the administration of alcohol t…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
Introduction. Artificial intelligence (AI) technologies are becoming crucial in clinical diagnostics due to their ability to process and interpret large volumes of data. The implementation of AI for biomarker analysis opens new opportunities in personalized me…
The development of metastases even long after treatment is one of the most important problems of medicine. There are mechanisms helping cancer cells to survive at various steps of metastasis. The ability of cancer cells to turn into dormant state characterizin…
Introduction. Many chemical compounds affect brain neurons differently than other cell populations. This is provided by the protective potential of the blood-brain barrier (BBB). One of the compounds capable of passing through the BBB is bacterial lipopolysacc…
Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize …
Introduction. The study of the effect of peroxynitrite, as a product of nitric oxide (II), on the culture of endothelial cells in vitro can contribute to fundamental ideas about the violation of the adhesive function of the endothelium when changing the synthe…
Introduction. An important pathogenetic link in systemic inflammation in ulcerative colitis (UC) is dysregulation of the immune response. The aim of the study: to study pathogenetic changes in the serum level of interleukin (IL)-4 during UC therapy. Methods. 6…