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Molecular Medicine
Found: 149
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
The review is devoted to the role of some signaling molecules produced by neuroendocrine and immune cells of the gastrointestinal tract (GIT) in the pathogenesis of the diseases of the digestive system. Special attention is paid to the key signaling molecules …
Based on literature data and analysis of own observation the hypothesis of pathogenesis of diffuse parenchymal lung osteodystrophy (DPLOD) is proposed. DPLOD is a very rare disease with unknown etiology. It is characterized by unilateral or bilateral lesions o…
The role of aromatase P450 in the pathogenesis of external genital endometriosis (IEG) has been investigated. 45 women with endometriosis have been included in the study, the group of comparison was consisted of 9 healthy women. The examination included a lapa…
Translational medicine is one of the critical components to overcome the impediments within the objectives of Predictive Preventive and Personalized Medicine. Identification of molecular mechanisms underlying subclinical stages of T1D pathogenesis is a key to …
This article discusses the current level of research on the molecular mechanisms of development and progression of chronic heart failure in elderly and senile age. Described contribute to the pathogenesis of diseases of various signaling molecules and subsyste…
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…