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Molecular Medicine
Found: 172
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
Introduction. Galectin-1 binds to cell surface glycoprotein and participates in cooperation of immune cells. It is supposed that the CD4+- lymphocytes can be target for immunosuppressive activity of galectin-1. However, there is no sufficient information about…
Introduction. Neuroendocrine cells are involved in multiple regulatory processes. In the article the attention is paid to the key signaling molecules that provide local interactions between neuroendocrine cells after radiation exposure. The aim of the study. T…
Introduction. Currently, the study of molecular and cellular bases for the development of frailty is an actual scientific problem. The aim of the article is to study the morphofunctional and cytochemical characteristics of erythrocytes in frailty patients. Met…
Introduction. In recent years among non-drug methods of treatment and rehabilitation of patients of elderly and senile age is a promising application of low-intensity millimeter waves as an important reserve of increasing the effectiveness of the complex thera…
Introduction. The prevalence of human cutaneous melanoma (CM) in the world is constantly rising. Diagnostics and treatment of CM at the early stages allows to increase the 5-year patient survival up to 90%. This problem can be solved with personalized therapy …
Lung cancer is one of the most common oncologic diseases in the world and the most frequent cause of the death from malignant neoplasms. Last decade’s studies revealed significant number of molecular events leading to the onset and development of non-small cel…
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
Introduction. The features of pathogenesis of main tumors of the female reproductive system are determined by the impact of estrogen on target tissues. In this connection there appears the need to study the regulation of estrogen and progesterone receptors in …
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …
Introduction. Insulin-like growth factors (IGFs) signaling system plays a key role in development and progression of various malignant tumors, and its components may be considered as prospective diagnostic and prognostic markers and potential objects of target…
The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in ather…
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
In the article a review of recent data on the molecular nature of neuroendocrine tumors of the pancreas (pancreatic NETs) is presented. The genetic basis of inherited syndromes associated with the development of pancreatic NETs: multiple endocrine neoplasia ty…
A literature review is devoted to the analysis of clinical significance of key factors of neoangiogenesis in ovarian cancer patients, their connection with the main clinical and morphological characteristics of the disease, prognosis, features an anti-angiogen…
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…
Abstract: This review summarizes the results of studies devoted to identification the dominant mechanisms of formation and persistence of inflammation in severe asthma. According to the latest research, the most likely causal factors and molecules that underli…