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Molecular Medicine
Found: 305
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…
The aim of this review is to analyze current understanding of the molecular mechanisms of altered sensitivity of the arterial baroreflex and peripheral chemoreflex and their potential association with perioperative complications. Material and methods. The revi…
Introduction. This review is devoted to the problem of the pathogenesis of pain syndrome in multiple myeloma (MM). The severity of pain often correlates poorly with the plasma cell burden but is highly dependent on tumor aggressiveness determined by primary ge…
coronary artery disease, epithelial-mesenchymal transition, cadherins, connexins, transforming growth factor-β, pannexins
Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…
Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…
Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …
Relevance. Modern approaches to detecting circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) demonstrate high potential for improving the accuracy of molecular diagnostics of tumors and require a comprehensive analysis of all stages, from the biology of f…
Introduction. Ovarian cancer is characterized by high mortality. Despite available diagnostic and therapeutic methods, patient survival remains unsatisfactory, especially for high-grade tumors, necessitating the exploration of new molecular targets. Heat shock…
Background. Pollinosis is a progressive allergic disease mediated by an IgE-dependent reaction associated with the activation of inflammatory processes, oxidative stress and lipid peroxidation, which affects, first of all, the membrane structures of various ce…
Introduction. The incidence of eosinophilic esophagitis is 5.31 cases per 100,000 person-years. It is a multifactorial disease with a clear genetic predisposition, specifically involving the expression of the thymic stromal lymphopoietin and IL-33 genes. Eosin…
Objective. To investigate the role of toxic metabolites of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in autism spectrum disorders (ASD) pathogenesis and their relationship with intestinal dysbiosis. Material and methods. The study included…
Introduction. Lymphogenous metastasis is a key stage in the progression of gastric cancer. The practice of personalized treatment has historically been based on histological and molecular analysis of the primary tumor, while the molecular-genetic landscape of …
Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…
Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…
Objective. Mixed organometallic complexes containing amino acids and water-soluble vitamins as ligands are promising research subjects in organic and physical chemistry. The practical applications of these compounds may include medicine, where they are conside…
Introduction. To date, digital twins are the most promising area for the development of modern healthcare. With their help, it is possible to radically change approaches to the diagnosis, treatment and prevention of diseases. In medicine, the concept of digita…
Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…
Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…