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Molecular Medicine
Found: 27
This review systematizes current data on branched-chain aminotransferases (BCATs). Their molecular structure, classification as fold type IV pyridoxal phosphate (PLP)-dependent enzymes, and catalytic features are discussed in detail. The differences between th…
Introduction. Breast cancer (BC) is a heterogeneous disease that represents a major global health problem. It is the most frequently diagnosed cancer in the world, with the incidence of breast cancer increasing year by year in most countries. The existence of …
Introduction. The main attention of researchers is paid to the study of one of the members of the EGF family – the receptor of epidermal growth factor 2 (Her2/neu), the overexpression of which is detected in 15–20% of cases of invasive breast cancer and had an…
Introduction. In recent years, alternative framework proteins are used for the targeted radionuclide imaging. Molecules of DARPin (Design Ankyrin Repeat Protein) are one of the representatives of scaffolds. Despite the continued increase in the number of molec…
Dendritic cells (DC), as professional antigen-presenting cells with functional plasticity, are widely studied in preclinical and clinical research of vaccines against various types of malignant tumors. Some of the studies DС have proved their efficiency. Howev…
Introduction. Breast cancer is the leading cancer type among woman of Azerbaijan population. Hereditary mutations of the BRCA1/2 genes are considered as high risk for appeared breast and ovarian cancers. In Azerbaijan BRCA1/2-related breast and ovarian cancer …
Background. Plasminogen activators play the leading role in the tumor growth and metastasis. Growth factors stimulate proliferative processes and are involved in neoangiogenesis. Aim of the study. Identification of changes in components of the fibrinolysis sys…
Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…
Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…
Introduction. Nuclear medicine imaging is widely used in oncology for the assessment of pathophysiologic changes occurring in a tumor. In this regard, the intensive study of diagnostic efficiency of the existing radiopharmaceuticals and the search for the new …
There is represented immunohistochemical and molecular biological characteristic of some histological types of breast cancer. The assessment of molecular biomarkers in breast cancer has two practical results: identification of risk groups, requiring additional…
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
Introduction. Epigenetic changes caused by methylation in promoter CpG-islands are a fine and dynamic mechanism of gene expression regulation in tumors. Increased and decreased expression and alterations in the methylation status of the gene are considered to …
Introduction. PI3K/Akt signaling pathway is an important intracellular regulatory mechanism controlling cues of growth factors stimuli, apoptosis, proliferation, and cell motility. Deregulation of activity/expression of PI3K/Akt signaling pathway proteins dete…
Introduction. Skeletal involvement is a frequent and troublesome complication of breast malignant tumors. The accurate diagnosis of bone metastasis and well-timed prescription of the antiresorptive therapy are essential for reducing both severity and mortality…
Introduction. The COMT gene encodes for a protein involved in deactivation of genotoxic estrogen species, and the protein product encoded by the L (low activity) allele is 3–5-fold less active than its counterpart encoded by the H (high activity) allele. The a…