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Molecular Medicine
Found: 11
Introduction. Breast cancer (BC) is a heterogeneous disease that represents a major global health problem. It is the most frequently diagnosed cancer in the world, with the incidence of breast cancer increasing year by year in most countries. The existence of …
Introduction. In recent years, alternative framework proteins are used for the targeted radionuclide imaging. Molecules of DARPin (Design Ankyrin Repeat Protein) are one of the representatives of scaffolds. Despite the continued increase in the number of molec…
Background. Plasminogen activators play the leading role in the tumor growth and metastasis. Growth factors stimulate proliferative processes and are involved in neoangiogenesis. Aim of the study. Identification of changes in components of the fibrinolysis sys…
Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
Introduction. PI3K/Akt signaling pathway is an important intracellular regulatory mechanism controlling cues of growth factors stimuli, apoptosis, proliferation, and cell motility. Deregulation of activity/expression of PI3K/Akt signaling pathway proteins dete…
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
The association of +/– polymorphic markers of GSTM1 and GSTT1 genes and Ile105Val polymorphic marker of GSTP1 gene with the risk of development of breast cancer (BC) and its histological subtypes was studied. We have showed an association of null genotypes of …
The dependence of biochemical markers of bone resorption (C-terminal telopeptide of type I collagen – b-CTx, deoxypyridinoline – DPID, tartrate-resistant acid phosphatase (TRAP) 5b) and osteosynthesis (bone alkaline phosphatase – BALP) on clinical manifestatio…