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Molecular Medicine
Found: 18
Introduction. Cardiovascular diseases are the main cause of death and disability in the world population. Serotonin plays a significant role in the development and progression of atherosclerotic processes due to its two classical functions – platelet aggregati…
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…
The study aims to analyze the dependence of an α1А-adrenoreceptor antagonist effectiveness on G-protein-coupled receptors (GPCRs) intracellular signaling in the passage of medium-sized calculi from the ureter. Material and methods. The study was prospective an…
Аim of the study was to evaluate the activity of receptors that control contraction (α2-adrenergic receptor, purine P2X1 and P2Y receptors, angiotensin AT1 receptor, TxA2 receptor) and relaxation of smooth myocytes (adenosine A2 receptor) during standard litho…
The reasons for the low efficiency of the α1A-blockers using in the scheme of lithokinetic therapy (LCT) remain unclear. The aim of the study was to evaluate the activity of the purinergic P2X1 receptor in the blockade of the α1A-adrenergic receptor during LCT…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Introduction. Human platelets maintain big reparative and regenerative potential. The biochemical content of platelet preparations seriously depends on methodic features. The aim of the study. To study cytokine content in different types of platelet soluble pr…
ntroduction. The aim of this study was to determine the prevalence rate of CYP2C19 alleles, associated with the risk of the resistance to clopidogrel and the development of thrombotic complications in patients with acute coronary syndrome (ACS) from Russian an…
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
The review presents data concerning the interaction of basic types of nanoparticles with human platelets in vitro and in vivo and biological results of this influence. The initial structure of nanoparticles and their biologically active cargo can both stimulat…
Introduction. Producing of combined biotransplants with human platelets may be accompanied by high rate of the loss of biological active platelet components. It is suggested to use blockers of platelet activity to fix these cells on adhesive substrate surface.…
Introduction. Cardiovascular diseases consistently occupy the first place among causes of death and disability in almost all developed countries. The main importance of this group of diseases have myocardial infarction. One of the causes of myocardial infarcti…
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…
Introduction. In the structure of gynecological diseases endometriosis ranks third after inflammatory disease and uterine fibroids. Despite intensive study of the pathogenesis of endometriosis, many of the key moments remained to be unclear. In this regard, it…
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
We applied software «Algokomb» to perform mathematical modeling of polypeptide molecules of glycoprotein IIb/IIIa (gpIIb/IIIa) receptor antagonists. The modeled compounds have been synthesized accordingly to the protocol of strategy FastMoc 0.25. The structure…
The morphological and functional study of platelets stained with vital fluorochrome dyes has been performed in the blood of 100 donors and 100 hematological patients with thrombocytopenia. In hematologic patients with clinically pronounced hemorrhagic syndrome…
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…