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Introduction. Macrophage polarization is a key mechanism of immune regulation that determines their functional plasticity. Depending on the microenvironment, macrophages differentiate into proinflammatory (M1, activated by IFN-γ and LPS) or anti-inflammatory (…
Relevance. Tuberculosis immunodiagnostics is based on the ESAT-6 and CFP-10 antigens (RD1 region of Mycobacterium tuberculosis), which are absent from BCG strains and form the antigenic basis of IGRA and TBST. Their clinical use requires consideration of sever…
Introduction. The antitumor effects of selenium compounds depend on their structure and biotransformation. Toxic metabolite formation may coexist with enhanced selenoprotein-mediated protection of tumor cells; chemical reactivity does not establish therapeutic…
Introduction. The efficacy of RNA interferon inducers depends not only on ligand structure and innate immune receptor engagement but also on the metabolic state of the target cell. Increasing evidence indicates that redox homeostasis, glutathione system parame…
Aim. To relate data on the molecular mechanisms of primary dysmenorrhea to the main dimensions of its clinical heterogeneity: pain severity and duration, systemic symptoms, response to nonsteroidal anti-inflammatory drugs (NSAIDs), and propensity to chronic pa…
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
Objective. To relate hormonal, osteoimmune, and metabolic regulation of bone remodeling during the menopause transition to clinical evidence. Material and methods. A narrative analysis covered publications identified through PubMed and journal and professional…
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
Material and methods. A literature search was conducted in the PubMed/MEDLINE, Web of Science, Scopus, eLibrary.Ru, and Google Scholar for the period from 2022 to 2026. The search string included the following keywords: “leiomyoma”, “uterine leiomyoma”, “fibro…
Objective. To systematically categorize contemporary approaches and technologies for visualizing structural components of the tissue microenvironment (TME), with a focus on the advantages, limitations, and data analysis strategies of multiplex immunohistochemi…