СYTOKINES FOR ALLERGIC DISEASES

Morozova O.V., Ospelnikova Т.P.

The majority of IgE binds with Fcε mast cells receptors. Repeated contacts between allergen and specific IgE on the surface of mast cells result in Fcε-receptors cross-linking, degranulation and release of inflammation mediators such as histamine, proteases, c…

INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF CHRONIC HEART FAILURE

The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of CHF. Material and methods. A analysis of the main foreign and domestic sources on PubMed, MedLine, eLIBRARY databases over the last 20 years has been ca…

COMPENSATORY MUTATIONS AS A MECHANISM FOR PRESERVING VIRULENCEAND VIABILITY OF DRUG-RESISTANT FORMS OF MYCOBACTERIUM TUBERCULOSIS

Tuberculosis remains one of the leading causes of death from infectious diseases in the world. According to WHO data, tuberculosis is diagnosed annually in more than 100 million people and causes 4.5 thousand deaths. Despite a steady decline in the main epidem…

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Potupchik T.V., Alikin Yu.S., Generalov S.V., Evert L.S., Tymchuk V.I., Khalakoeva D.A., Abdullaeva S.R., Spitsyn А.А

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

Blood exosomes of patients with malignant neoplasms of bones and articular cartilage: connection with tumor progression and practical value in clinical medicine

Olgin O.E., Zheravin A.A., Aliev M.D., Choynzonov E.L., Chernyshova A.L., Tamkovich S.N.

Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…

A study of the transformation of digital twins into personalized medicine

Seliverstov P.V., Kryukov Е.V., Grinevich V.B., Ivchenko E.V., Minakov E.P.

Introduction. To date, digital twins are the most promising area for the development of modern healthcare. With their help, it is possible to radically change approaches to the diagnosis, treatment and prevention of diseases. In medicine, the concept of digita…

Molecular markers of the development of posttraumatic stress disorder

Kolpakova M.E., Pyanzin S.Yu.

Introduction. Posttraumatic stress disorder (PTSD) is presented as a systemic multilevel metabolic-immuno-psycho-neurological disorder with genetic predisposition and epigenetic influences, which radically changes the approach to its understanding and treatmen…

Selenium: biochemical role and the importance of balance in the human body

Deeva T.A., Tyagunov E.G., Zolnikova O.Yu.

The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…

Matrix Metalloproteinase Polymorphisms as Predictors of Osteoarthritis

Voronova A.N., Plekhova N.G.

This review was conducted to systematize data on the association of matrix proteinase gene polymorphisms (MMP, ADAMTS, ADAM) with the risk of developing osteoarthritis. Material and methods. A systematic literature search of PubMed and Web of Science databases…

Immunopathology of trauma: relationship between physical damage to the musculoskeletal system and the development of rheumatic diseases

Karateev A.E., Polishchuk E.Yu.

Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…