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Molecular Medicine
Introduction. Based on current literature data, it is possible to assume that when exposed to glioma cells astrocytes, may undergo a reactive transformation. These glioma-conditioned astrocytes might create a permissive environment for tumorigenesis. The aim o…
Introduction. Successful embryonic development immediately after fertilization depends on the maternal messenger RNAs (mRNAs) destruction and zygotic genome transcription activation during maternal to zygotic transition (MZT). Key regulators of MZP are small n…
The review considers the role of hyaluronic acid (HA), primarily low-molecular-weight fractions of HA, in the regulation of the cell cycle of tumor cells. The formation of a pool of low-molecular weight HA molecules is due to the high activity of hyaluronidase…
Introduction. The main function of alpha-1 antitrypsin (A1AT) is inhibition of neutrophil elastinase and control over TNFα secretion. Anti-inflammatory properties of A1AT are manifested in leucocyte migration decrease and proliferation of T-lymphocytes through…
Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG eff…
Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…
Introduction. The pathological state of hypoxia of the body occurs with an inadequate supply of tissues and organs with oxygen or with a violation of its utilization in the process of biological oxidation. Ethylmethylhydroxypyridine has a multi-component mecha…
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …
The review considers the system of hyaluronic acid (HA), represented by its receptors, the enzymes of synthesis (hyaluronan synthase), cleavage (hyaluronidase). The participation of the HA system in the regulation of the cell cycle was demonstrated. The most i…
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …
Introduction. The specific activity of blood coagulation factor VIIa depends, among other things, on the presence of N-acetylneuraminic acid (sialic acid) and phosphate residues in the molecule. Thus the authenticity of glycosylation profile as one efficacy an…
Introduction. The decline in collagen I type synthesis and the gain in matrix metalloproteinases (MMPs) activity are the main characteristics of the molecular skin aging. MMPs are ferments which cleave collagen. The aim of the study was to investigate the infl…