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Molecular Medicine
Pre-metastatic niche formation precedes tumor dissemination although the mechanisms of it remain unclear. Therefore, the aim of the study was to evaluate the expression of molecules characterizing the microenvironment remodeling in target organs lungs and live…
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…
Introduction. It was shown, that L-amino acids can take part in regulation of the main physiological processes. Various combination of L-amino acids takin into account of its biological activity can apply for peptide drugs synthesis for target therapy of socia…
Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to …
The purpose of this review was to describe information about the etiology and pathogenesis of the main manifestations in patients with coronavirus infection COVID-19 and the molecular mechanisms of the possible use of metabolite drugs. Material and methods. Th…
MicroRNAs are defined as short non-coding molecules that regulate gene expression at the post-transcriptional level through complementary binding to the corresponding mRNA. This pairing leads to inhibiting of further translation by mRNA degradation, in other w…
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…
The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «nor…
Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …
The aim of the study was to study the effect of chemical immobilization of yeast cell wall glycoproteins on their ability to activate cytokine production by human peripheral blood cells. Methods. A comparative analysis of the immunomodulatory activity of yeast…