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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

Articles

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 33–38

RELATIONSHIPS OF HEMOSTASIS INDEXES AND MICROCIRCULATORY HEMODYNAMICS INDICATORS IN KNEE AND HIP JOINT TRANSPLANTATION

Aim of investigation. The development of a non-invasive express method for assessing the state of the hemostasis system during transplantation of large joints is an urgent task, since it allows you to adjust the appointment of anticoagulant therapy and prevent…

10.29296/24999490-2022-06-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 50–55

OUTCOMES OF TUBERCULOSIS COMBINED WITH HIV INFECTION

Introduction. The epidemiological process in tuberculosis is negatively affected by the HIV epidemic, the identification of vulnerable groups in relation to the unfavorable course of tuberculosis in combination with HIV infection will improve approaches to tre…

10.29296/24999490-2022-06-08Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 56–64

CORRECTION OF ALCOHOL-INDUCED DISORDERS OF WORKING MEMORY WITH NOOPEPT

Introduction. Nootropic drugs are used at all stages in treatment of behavioral disorders associated with alcohol consumption, when the correction of the functions of operational (working) memory and attention contributes to a more adequate processing and assi…

10.29296/24999490-2022-06-09Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 59–64

ANTIGENOTOXIC ACTIVITY OF THE COMBINATION «ASPARTAME + BETAINE» AND METFORMIN IN MICE WITH EXPERIMENTAL STREPTOZOTOCIN DIABETES

Introduction. An increase in DNA damage (genotoxicity) is characteristic of patients with diabetes mellitus. The main complications in diabetes are accompanied and/or initiated by DNA damage. Hence, the necessity to search for and study compounds with antigeno…

10.29296/24999490-2022-05-08Details ↗
ОБЗОР2022 · pp. 18–27

FIBROBLAST GROWTH FACTORS AND THEIR EFFECT ON COGNITIVE FUNCTIONS AND THE COURSE OF CENTRAL NERVOUS SYSTEM DEGENERATIVE DISEASES

Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man factor FGFd, including 22 structurally connected polypeptides, is necessary for the neuroprotection by the CNS degenerative pathology is presented playing a great …

10.29296/24999490-2022-05-03Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 28–33

THE ROLE OF MARKERS OF INTERCELLULAR INTERACTION IN THE DEVELOPMENT OF ATOPIC DERMATITIS

Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…

10.29296/24999490-2022-05-04Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 34–41

EFFECTIVENESS OF α1А-ADRENORECEPTOR ANTAGONIST IN THE PASSAGE OF MIDDLE STONES FROM THE URETER: THE ROLE OF RECEPTORS COUPLED WITH G-PROTEIN

The study aims to analyze the dependence of an α1А-adrenoreceptor antagonist effectiveness on G-protein-coupled receptors (GPCRs) intracellular signaling in the passage of medium-sized calculi from the ureter. Material and methods. The study was prospective an…

10.29296/24999490-2022-05-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 42–52

ASSOCIATION OF POLYMORPHIC VARIANTS OF NON-ALLELIC GENES ADIPOQ, MTHFR, PON1, KCNJ11, TCF7L2, ITLN1 AND PPARG WITH CLINICAL AND LABORATORY PARAMETERS AMONG OBESE PATIENTS FROM KYRGYZ REPUBLIC

Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…

10.29296/24999490-2022-05-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 53–58

INFLUENCE OF GABA DERIVATIVES ON THE DNA DAMAGE OF PLACENTA AND FETUSES’S BRAIN AT EXPERIMENTAL PREECLAMPSIA

Gestosis is a complication of the normal course of the gestational process that occurs during pregnancy, childbirth and in the first days of the postpartum period, characterized by a deep disorder of the functions of vital organs and systems. Preeclampsia (PE)…

10.29296/24999490-2022-05-07Details ↗
ОБЗОР2022 · pp. 9–15

SASP OF ENDOTHELIUM AND VASCULAR SMOOTH MUSCLE CELLS: ROLE IN THE PATHOGENESIS AND THERAPY OF ATHEROSCLEROSIS

The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…

10.29296/24999490-2022-04-02Details ↗

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