This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Introduction. An increase in the number of patients with atopic dermatitis (AD) among pregnant women is recorded annually. However, the pathogenesis of AD during pregnancy is not fully understood. Exacerbations of AD during pregnancy require in-depth study, si…
It is currently being discussed that the microbiota of the gastrointestinal tract and its metabolites affect the course of bronchial asthma (BA). The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of ВА. Ma…
Introduction. Small cell lung cancer (SCLS) is a highly aggressive type of tumor, and various compounds are considered as potential biochemical markers of its prognosis, including neuron-specific enolase (NSE), chromogranin A (CgA), and prograstrin releasing p…
Tripeptides are physiological products of protein degradation and informational molecules. AED (Ala-Glu-Asp), EDR (Glu-Asp-Arg), EDG (Glu-Asp-Gly) peptides have geroprotective, neuroprotective, reparative and antioxidant properties. The aim of the work is to e…
Introduction. In 2013 The Cancer Genome Atlas research group divided the molecular aberrations in endometrial cancer into four subtypes: POLE mutations, microsatellite instability, copy-number low and copy-number high. These subtypes have different prognosis a…
Introduction. Lactic acid bacteria synthesize antimicrobial substances of various nature: acids, alcohols, diacetyl, reuterin, hydrogen peroxide, carbon dioxide, etc. The Food and Drug Administration (USA) and the European Food Safety Authority have recognized…
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
Introduction. Buccal epithelium (BE), in which cells the expression of signal molecules reflecting the state of homeostasis of the body in normal and pathological conditions is verified, is used as a diagnostic material for a number of diseases in adults. The …