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Molecular Medicine
The review is devoted to problems of quality assessment of recombinant coagulation factors approved in the Russian Federation. The list of recombinant blood coagulation factor products approved in the world was provided. Benefits of the use of recombinant bloo…
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
Introduction. There is observed an incidence rate of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The aim of the study. The study of the quantitative density of mast cells of the colon; enterochromaffin cells secreting serotonin, melat…
Introduction. In the structure of gynecological diseases endometriosis ranks third after inflammatory disease and uterine fibroids. Despite intensive study of the pathogenesis of endometriosis, many of the key moments remained to be unclear. In this regard, it…
The aim of the study. The clinical study of the efficacy and safety of the novel pharmaceutical composition Cervicon-DIM on the base of diindolylmethane (DIM) in vaginal suppository form in the course of the conservative treatment of cervical intraepithelial n…
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
Introduction. To date, the mechanisms underlying the majority of cardiac arrhythmias are unclear. The disturbance of sympathetic innervation of the heart may be as well the cause of atrial fibrillation (AF), as the reason of myocardial dysfunction of the left …
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…