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Molecular Medicine
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Hemophilia A is a frequent X-linked recessive disorder associated with the absence or functional defect of blood clotting factor VIII. Вoth point mutations and large structural rearrangements – deletions, duplications, and inversions were describ…
Introduction. Endometriosisis a commonovarianhormone-dependent diseasesin womenof reproductive age. Lack ofeffectiveness of treatmentof this diseasemay be associatedwith gapsof knowledgeabout the molecular mechanismsof its originand development. The aim of the…
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
Introduction. Genetic predispose to ischemic heart disease (CHD) are the priority directions in the study of etiological factors this condition. The aim of the study. Association analysis of polymorphism in modifying genes for blood pressure and genes for immu…
Introduction. The central role in the pathogenesis of Crohn's disease (CD) is given an immune disorder. Communication immunohistochemical characteristics of the mucous membrane with the outcome of the disease has not been studied. The aim of the study. The aim…
The aim of the study. The proof of afobazole efficacy for treatment and prevention of alcoholic cardiomyopathy and attendant complications using the previously developed translational model. Materials and methods. Alcoholic cardiomyopathy was produced by conti…
Introduction. Insulin-like growth factors (IGF) signaling system plays a major role in the development and progression of various sarcomas and other solid tumors, and therefore its components are regarded as promising diagnostic and prognostic tumor markers an…
Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…
Introduction. Currently in the world there are conducted numerous studies on the search for biomarkers associated with increased risk of coronary heart disease (CHD). The aim of the study. The study of the levels of such inflammatory biomarkers as the tumor ne…