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Molecular Medicine
Background. Bronchobstructive diseases are accompanied by changes in autonomic and hemodynamic regulation. Nonlinear characteristics of circulatory rhythms may serve as integrative functional features of individual rehabilitation response, but they are not dir…
Objective. The extracellular matrix (ECM) plays a key role in glioblastoma (GB) progression by shaping an immunosuppressive tumor microenvironment and acting as a drug penetration barrier. This study performed an integrative analysis of seven publicly availabl…
Introduction. Radiotherapy carries a risk of liver damage: radiation-induced liver disease develops in 5 – 10% of cases after gamma-irradiation at 30 Gy, driven by oxidative stress and depletion of endogenous antioxidant defense. Existing radioprotectors, such…
Introduction. Colorectal cancer (CRC) remains one of the leading oncological diseases, the development of which is accompanied by characteristic epigenetic changes. The most significant of these is the hypermethylation of the SEPT9 gene, detected both in tumor…
Introduction. Despite research into the pathogenesis of depression in PD, there is still no unified theory regarding its onset. Objective: To evaluate the expression of tyrosine hydroxylase (TH) and 3-nitrotyrosine (3-NT) in brain structures using models of PD…
Objective. To assess the association of age, anaemia, impaired renal function and concomitant therapy with direct oral anticoagulant (DOAC)-related outcomes in patients aged 60 years and older with multimorbidity and polypharmacy. Material and methods. This pr…
Introduction. The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is based on lipid accumulation in hepatocytes accompanied by oxidative stress and the development of steatohepatitis, whereas the etiology of alcoholic liver disease (ALD) is associate…
Background. Hypoxic training are actively used in both professional and amateur sports. Hypoxia triggers a number of adaptive mechanisms aimed at improving stamina. However, these compensatory and adaptive pathways can be activated through rational pharmacolog…
Introduction. Body mass index remains a convenient screening tool but fails to capture fat distribution, body composition, molecular inflammatory status, psychobehavioral features, or obesity-related end-organ dysfunction. Objective. To develop and substantiat…
Introduction. Plant biologically active compounds are considered as potential means of correcting reproductive function in obesity, but the molecular and cellular mechanisms of their action remain poorly understood. The purpose of the study. To study the effec…