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Molecular Medicine
Introduction. Post-transcriptional and post-translational modifications of the alpha-synuclein protein are considered important links in the pathogenesis of Parkinson’s disease (PD) and multiple system atrophy (MSA). Regulation of mRNA stability and translatio…
Introduction. The Gly-His-Lys (GHK) peptide, which is a fragment of type I collagen, has a wide range of biological effects, including neurotropic ones, and has an anxiolytic and analgesic effect. However, GHK is susceptible to proteases and various proline-co…
Introduction. Non-communicable diseases develop long before clinical manifestation, and their subclinical signs may be missed by one-dimensional risk assessment. A holistic multiprofile approach combining somatic, psychoemotional and behavioural determinants m…
Introduction. Metabolic syndrome is a cluster of interrelated disorders of carbohydrate and lipid metabolism and requires reproducible experimental models suitable for pharmacological screening. Long-term exposure of laboratory animals to high-calorie diets ca…
Aim of the study was to establish the relationships between vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF-BB), and transforming growth factor β1 (TGFβ1) and clinical diagnostic parameters in patients with diabetic foot syndrom…
Introduction. Cancer patients have a high risk of developing venous thromboembolic complications, which worsen the outcomes of antitumor treatment and are the second leading cause of death after cancer progression. Objectives – to assess the effect of modern a…
Introduction. Arterial hypertension (AH) and obesity form a common cardiometabolic phenotype, in which hemodynamic overload, dysfunctional adipose tissue, estrogen deficiency, dyslipidemia, endothelial dysfunction, vascular remodeling, and electrophysiological…
Introduction. Primary open-angle glaucoma is considered a multifactorial disease, in the pathogenesis of which low-grade inflammation, cytokine imbalance, extracellular matrix remodeling, and neuroinflammation play a significant role. In comorbid patients with…
Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…
Introduction. Obesity can no longer be adequately described by body mass index alone. Similar BMI values may coexist with different fat distribution, inflammatory burden, neuroendocrine dysregulation, psychobehavioral traits, and risks of organ dysfunction. Ob…