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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017

THE PROBLEMS OF BIOCOMPATIBILITY OF TITANIUM AND HAFNIUM NITRIDE-BASED COATING METALLIC IMPLANTS FOR OSTEOSYNTHESIS

Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provi…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017

CONTRACTING CAPACITY OF EMBRYONIC FIBROBLASTS WITH VARIED REGENERATIVE POTENTIAL

Introduction. Contracting deep scars are almost unresponsive to conservative treatment and often require repeated surgical intervention. These scars represent a serious problem in skin therapy after the extensive damage. Just the impairment of processes of the…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017

CLINICAL SIGNIFICANCE OF GENE CYP2C19 POLYMORPHISM IN STEMI PATIENTS (DATA FROM THE KEMEROVO REGISTRY OF THE ACUTE CORONARY SYNDROME)

Aim is to evaluate distribution and clinical significance of gene CYP2C19 polymorfism in ST-segment elevation myocardial infarction (STEMI) patients. Materials and methods. A total of 159 patients were encluded in this study. All of them underwent primary PCI.…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

SIGNIFICANCE OF EXPRESSION OF MOLECULAR MARKERS IN DIAGNOSTICS OF PRECANCEROUS LESIONS AND TRANSFORMATIONS OF GASTRIC MUCOSA

Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

METHODICAL ASPECTS OF USING RAT RBL-2H3 BASOPHILS FOR DEGRANULATION STUDY

Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

INFLUENCE OF THE EXPRESSION OF E7 PROTEIN ON GROWTH FACTORS AND MARKER OF SQUAMOUS CELL CARCINOMA SСC IN THE TISSUE OF CERVICAL CANCER

Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

MOLECULAR AND CELLULAR FACTORS OF LOCAL IMMUNITY IN ASCITIC FLUID OF OVARIAN CANCER PATIENTS

Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

THE INFLUENCE OF FUNCTIONAL POLYMORPHISM IN THE GALANIN PROMOTOR ON GLATIRAMER ACETATE EFFICACY IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

Introduction. Glatiramer acetate (GA, copaxone) – is an immunomodulatory drug, used for reducing the progression of multiple sclerosis. The absence of optimal therapeutic effect in some cases determines the necessity to search the prognostic markers of GA effi…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

INFLUENCE OF AFOBAZOL ON THE LEVEL OF INDUCIBLE NO-SYNTHASE IN ISCHEMIC MYOCARDIUM

The purpose of this study. Evaluation the effect of Afobazol on the level of myocardial inducible NO-synthase (iNOS) in the ischemic myocardium in rats. Methods. Myocardial ischemia was produced by the Selye’s method. The of inducible NO-synthase level on the …

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