VASCULAR TROPIC SIGNALING MOLECULES EXPRESSION IN THE PLACENTALTISSUE SAMPLES FROM PUERPERAE WITH GESTATIONAL DIABETES MELLITUS

The assessment of vascular endothelial growth factor (VEGF) and endotelial NO – synthase (eNOS) expression levels in placental tissue
samples obtained from pregnant females with gestational diabetes mellitus (GDM) has been performed. The highest level of these vasoactive
factors expression was displayed to be in placental tissue samples from GDM puerperae who received nutritional therapy, and the lowest
expression level was detected in PTS from GDM patients receiving insulin therapy. It can explain bigger rate of adverse perinatal outcomes in
pregnancy with poorly controlled diabetes mellitus and high degree of hyperglycemia, typical for patients receiving insulin therapy.

R.V. Kapustin, O.N. Arzhanova, V.O. Polyakova
Federal State Budgetary Institution «D. O. Ott Research Institute of Obstetrics and Gynecology» of the Russian Academy of Medical Sciences, Saint-Petersburg, Russia