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Molecular Medicine
Found: 261
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…
Relevance. PARP inhibitors (PARPi), have emerged as a significant development in the treatment of high-grade serous ovarian cancer that is associated with mutations in BRCA1/2 and genes of other homologous recombination proteins. These drugs exploit synthetic …
Introduction. Primary open-angle glaucoma is considered a multifactorial disease, in the pathogenesis of which low-grade inflammation, cytokine imbalance, extracellular matrix remodeling, and neuroinflammation play a significant role. In comorbid patients with…
Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…
Introduction. Obesity can no longer be adequately described by body mass index alone. Similar BMI values may coexist with different fat distribution, inflammatory burden, neuroendocrine dysregulation, psychobehavioral traits, and risks of organ dysfunction. Ob…
Introduction. Microglia initiate and play a key role in neuroinflammation, which is currently considered one of the main mechanisms of neurodegeneration in Alzheimer’s disease. The aim of this study was to analyze the morphofunctional characteristics of microg…
Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…
Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …
Relevance. Modern approaches to detecting circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) demonstrate high potential for improving the accuracy of molecular diagnostics of tumors and require a comprehensive analysis of all stages, from the biology of f…
Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…
Introduction. The article is devoted to the theoretical prediction of the spatial structure of proteins of protein three-dimensional structures, with a focus on the specifics of modeling chemical compounds containing a significant number of amino acid residues…
Background. Pollinosis is a progressive allergic disease mediated by an IgE-dependent reaction associated with the activation of inflammatory processes, oxidative stress and lipid peroxidation, which affects, first of all, the membrane structures of various ce…
Introduction. The incidence of eosinophilic esophagitis is 5.31 cases per 100,000 person-years. It is a multifactorial disease with a clear genetic predisposition, specifically involving the expression of the thymic stromal lymphopoietin and IL-33 genes. Eosin…
Introduction. Lymphogenous metastasis is a key stage in the progression of gastric cancer. The practice of personalized treatment has historically been based on histological and molecular analysis of the primary tumor, while the molecular-genetic landscape of …
The aim of the review is to analyze the main trends in the development of molecular medicine and to establish the dependence of the development of modern informative diagnostic tests and treatment methods on new knowledge about the biochemical processes develo…
Introduction. Male infertility is a complex medical problem affecting a significant part of the male population. According to the WHO, about 15% of couples worldwide face infertility problems, and in 40-50% of cases the cause is attributed to the male factor. …
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
The pathogenetic process of sarcopenic obesity (SO) development is multifactorial, the key of them is considered – non-specific systemic inflammation. Objective. to assess the influence of the intensity of the course of chronic inflammation in patients with ty…
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…