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Molecular Medicine
Found: 34
Introduction: Urate nephrolithiasis is a common form of urolithiasis. The development of new methods for pharmacological correction of this disorder requires their practical laboratory assessment. So far, it is necessary to determine the most typical biochemic…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
Introduction. The development of neurodegeneration in Alzheimer’s disease is inextricably linked with oxidative stress, a marker of which is oxidative protein modification. In the tissues of the brain, cerebrospinal fluid and plasma in Alzheimer’s disease, an …
Introduction. Revealing the relationship between the severity of oxidative stress and the activity of cathepsins in tissues (plasma and blood cells) readily available for the diagnosis of Alzheimer’s disease can be useful for understanding the pathogenesis of …
This review article focuses on modern ideas about the role of neurotrophic factors (BDNF, NGF, NRG1, etc.) in the formation of the placenta and their impact on the development of the fetal nervous system in early ontogenesis. Data on the common effect of neuro…
Introduction. Prolapse of pelvic organs being extremely common in the female population, hence, it is important to search for factors of prolapse pathogenesis to identify markers of the optimal time for surgical intervention. The aim of the study is to investi…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…