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Molecular Medicine
Found: 305
The content of VEGF and some components of plasminogen activation system (uPA, PAI-1 and tPA) was determined by enzyme immunoassay methods in the tumors from 121 endometrial cancer patients and in 18 samples of endometrial hyperplasia. Concentrations of uPA an…
The results of biodistribution of intravenously administrated 188Re-zoledronic acid in rats’ body on the model of bone lesions (callus) are presented. Experiments showed that the complex of 188Re-zoledronic acid has the bone-seeking distribution (up to 31,8% I…
Regulatory T-cells CD4+CD25+FoxP3+CD127low (Тregs) belong to the family of CD4+ T-cell subpopulation. Tregs display the suppressive activity and play a critical role in regulation and maintenance of autotolerance and immune homeostasis. The generation and diff…
The article presents results of a comparison of clinical, genealogical and molecular genetic data of the study of the role of gene polymorphisms of renin - angiotensin system (REN (G83A), AGT (M235T), AGTR1 (A1166C)) in children with hypertension, with taking …
RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with d…
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
Abstract: This review summarizes the results of studies devoted to identification the dominant mechanisms of formation and persistence of inflammation in severe asthma. According to the latest research, the most likely causal factors and molecules that underli…
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
Last successful results in target therapy of cancer were achieved with different tyrosine kinases inhibitors (TKI). Target therapy of non-small cell lung cancer (NSCLC) with EGFR inhibitors gefitinib and erlotinib is effective only in patients with somatic mut…
There are many applications of biosensors in biochemical analysis. High specifity of biorecognizing element that allows to carry out a quantitative analysis of complex analytes with high accuracy and to detect ultrasmall concentration of the certain molecules …
Based on literature data and analysis of own observation the hypothesis of pathogenesis of diffuse parenchymal lung osteodystrophy (DPLOD) is proposed. DPLOD is a very rare disease with unknown etiology. It is characterized by unilateral or bilateral lesions o…
Leiomyoma is one of the most common benign tumors of the female reproductive system. As this pathology in most cases is hormone dependent, we determined the level of gene expression of steroid receptors ERs, PR, estrogen sulfotransferase SULT1E1, STS steroid s…
Argirophilic proteins of nucleolar organizer regions (Ag-NOR) pose a wide group of nucleolar proteins specifically stained by AgNO3. Expression level of Ag-NOR proteins in proliferating cells, including tumor ones, is commonly high. Nucleophosmin/B23 and nucle…
Buccal epithelium (BE) is an easily accessible target for molecular diagnosis of various diseases, and non-invasive way to get it is possible. This review summarizes the results of studies indicating a change in the expression of various signaling molecules an…
There is a growing body of evidence confirming the validity of the concept of cancer stem cells (CSCs). It is becoming increasingly obvious that CSCs, possessing higher tumorigenicity, metastasis-initiating activity and chemoresistance, are a source of tumor g…
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
In a series of laboratory experiments on the surface of dentin treated with etching gel – 38% Phosphoric Acid, and exposed to 95% ethanol solution for 30 days at ambient temperature the crystal structures have been found. Three-Dimensional Visualization of the…
In autoimmune diabetes mellitus (IDDM), clinical manifestation is typically preceded by several years of latent autoimmune insulitis. The autoimmune process arises only in genetically predisposed people,and is usually provoked by an infectious pathogen. Dagnos…
The expression of signal molecules RON, CD90, CD73, СD64, Pax6, Chx10, RTF1, Oct2, which characterized the status of local and system homeostasis have been verified in the buccal epithelium from women with breast cancer. The most important markers, correlated …