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Molecular Medicine
Found: 348
Introduction. Hypertrophic cardiomyopathy (HCM) is a common genetically heterogeneous disease caused by mutations in genes encoding proteins of the cardiac sarcomere. Mutations in the genes encoding β-myosin heavy chain (MYH7) and myosin binding protein C (MYB…
Introduction. Rett syndrome (RTT) is the most common genetic syndrome underlying mental retardation and autism in girls. Etiology of this disorder is related to mutation in the MECP2 gene. However, there are many cases of this disease without the MECP2 mutatio…
Introduction. One of the main types of a hormonal therapy in the treatment of the cancer of the prostate gland is the antagonists of the NR3C4 (nuclear receptor subfamily 3, group C, member 4) receptor. It blocks binding of man’s hormones with receptors site, …
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
Implantation is the key process for becoming pregnant. Failure of implantation in IVF cycles is one of the main problems of modern reproductology. Search for biomarkers and the determination of the best time and maximal endometrial receptivity for the implemen…
Education in medicine has been facing a challenging problem of relations between basic biomedical sciences and clinical medicine. In postgenomic era emerging didactic issue is related both to contents and quantity of knowledge to be studied. Qualitative and qu…
«Nothing in biomedicine makes sense except in the light of evolution». From this point of view, genetics of predispositions hasto answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neut…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Introduction. The paper presents basic information about the modern role of the IMF in various biochemical processes. Emphasis is placed on the role of MMPs in the pathogenesis of periodontitis. These published data suggest ambiguity of scientific views on the…
Introduction.Transitional cell carcinoma of the bladder is the second most common malignancy of the genitourinary tract. Cystoscopy and urine cytology are the traditional most used techniques for diagnosis and surveillance of superficial bladder cancer. Urinec…
Introduction.Study of the influence of molecular and genetic predisposition to forecast neurorehabilitation patients with stroke is of great scientific and practical importance. The aim of the study.Determining the impact of allelic polymorphism Val66Met BDNF …
Introduction. Breast cancer pathogenesis is associated with alterations in processes of regulating of IGF effects and also in IGF-signaling pathway activation. The direct correlation between high IGF blood serum levels and the rescue of malignancies in prostat…
Based on literature and own data the role of genotoxic events in nosogenesis of hereditary, congenital and somatic diseases is considered. Special emphasis is paid to the analysis of significance of premutagenic DNA lesions and as well induced gene mutations i…
Formation of an effective strategy for managing patients after implantation of an artificial heart valve (АНV), in order to prevent thrombotic complications is an important problem in cardiology. The use of indirect anticoagulants, including warfarin reduces t…
The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in ather…
Salinomycin is referred to the group of the polyether antibiotics with ionophore activity. Currently salinomycin is considered as a potential anticancer drug. The aim of this work was to investigate the cytotoxic activity of salinomycin against MDR1+ (Mel-8) a…
The original selective blocker of voltage-transmembrane potassium channels pharmacological drug cardiocyclide (N-[2-(dicyclohexylamino)- 2-oxoethyl]-N-[3-(diethylamino)propyl]-4-nitrobenzoic carboxamide hydrocloride) has been earlier synthesized and pharmacolo…
The influence of the DNA minor groove binding ligands on epigenetic silencing in eukaryotic human cells has been demonstrated for the first time. Using HeLa cell population that harbors silent GFP-reporter gene under control of the CMV promoter we demonstrated…
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…
The article provides a brief overview of the evolution of views on the phenomenon of pleiotropy. We discuss with assessment of pleiotropic effects significance in the formation of human pathological states, above all – multifactorial diseases (MFD). Pleiotropi…