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Molecular Medicine
Found: 559
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
Sertoli cells are the primary cells that support developing spermatogenic cells in the seminiferous tubules. Heat treatment induces a reversible change in the Sertoli cells (SC) from the mature differentiated state to an immature-like dedifferentiated state. W…
reduced levels of monocytic TF expression in comparison with homozygous ones (160,1±53,0% and 198,6±72,9% M±SD, accordingly). If compared with homozygous allelic variants D-1208I heterozygous genotype is associated with less macrophagic TF expression in lungs …
The association of +/– polymorphic markers of GSTM1 and GSTT1 genes and Ile105Val polymorphic marker of GSTP1 gene with the risk of development of breast cancer (BC) and its histological subtypes was studied. We have showed an association of null genotypes of …
In autoimmune diabetes mellitus (IDDM), clinical manifestation is typically preceded by several years of latent autoimmune insulitis. The autoimmune process arises only in genetically predisposed people,and is usually provoked by an infectious pathogen. Dagnos…
The effect of PABA in rd10 mice on photoreceptor survival, rhodopsin, blue opsin and red/green opsin contents were quantified in retinal sections using immunofluorescent techniques. The red/green cone opsin content was significantly higher in the retina of rd1…
Translational medicine is one of the critical components to overcome the impediments within the objectives of Predictive Preventive and Personalized Medicine. Identification of molecular mechanisms underlying subclinical stages of T1D pathogenesis is a key to …
Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and regulated as a function of their size, shape, surface chemistry and interior void space. Dendrimers are hyperbranched polymers with unique physical and chemical properties…
The associations of polymorphic markers of the xenobiotics – metabolizing genes (GSTТI, GSTМI, GSTPI), cell cycle regulation genes (ТР53,CDKNI) and of the gene XRCCI repairing damaged DNA bases in 54 healthy subjects and 50 patients with upper respiratory trac…
Reprogramming of human cells without genetic modification is increasingly used technology in experimental cell biology. One of these promising methods is the transfection of synthesized mRNA of transcription factors. In this study we synthesized a modified mRN…
This article discusses the current level of research on the molecular mechanisms of development and progression of chronic heart failure in elderly and senile age. Described contribute to the pathogenesis of diseases of various signaling molecules and subsyste…
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…
The purpose of this study was to determine the influence of transcardial perfusion, as well as social hierarchy in male mice, on the level of gene expression in the cerebral cortex of mice using the example of the proinflammatory cytokine IL-1β. Material and m…