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Molecular Medicine
Found: 17
Introduction. Breast cancer (BC) is a heterogeneous disease that represents a major global health problem. It is the most frequently diagnosed cancer in the world, with the incidence of breast cancer increasing year by year in most countries. The existence of …
Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
Introduction. Currently, clinical diagnosis of myocarditis is a difficult task. The diagnosis of the disease is made on the basis of category IV criteria, which include data of electrocardiography, Holter monitoring, echocardiography and MRI, laboratory biomar…
MicroRNAs are defined as short non-coding molecules that regulate gene expression at the post-transcriptional level through complementary binding to the corresponding mRNA. This pairing leads to inhibiting of further translation by mRNA degradation, in other w…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
This review attempts to generalize current data on the role of microRNAs in the pathogenesis of endometriosis and their pathogenetic relationship with the main pathomorphological phenomena in this pathology. Nowadays, many microRNAs were studied to clarify the…
Communities of microorganisms are a set of species that interact with each other and occupy the same niche where competitive or mutually beneficial relationships can occur. Biofilms are only one of many types of microbial communities, the study of which has be…
Introduction. Successful embryonic development immediately after fertilization depends on the maternal messenger RNAs (mRNAs) destruction and zygotic genome transcription activation during maternal to zygotic transition (MZT). Key regulators of MZP are small n…
Epigenetics studies inherited mechanisms capable of modulating gene expression without altering the DNA nucleotide sequence. Until very recently, epigenetics included inherited mechanisms, such as DNA methylation and histone modification. As of today, a large …
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
Introduction.Transitional cell carcinoma of the bladder is the second most common malignancy of the genitourinary tract. Cystoscopy and urine cytology are the traditional most used techniques for diagnosis and surveillance of superficial bladder cancer. Urinec…