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Molecular Medicine
Introduction: Studying the relationship between functional dyspepsia and gut microbiota will provide insight into the role of individual microorganisms and their metabolic products in the development of this pathology. The aim of the study was to analyze the m…
Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…
Atherosclerosis and the installation of stents can be considered as a model of premature aging of the body. These processes are associated with chronic inflammation, oxidative stress, loss of cellular function, and impaired regeneration, which makes them a con…
Purpose of the review. The purpose of this review was to summarize the available relevant data on pathogenetic mechanisms in the formation of steroid resistance in severe bronchial asthma. Material and methods. The analysis of domestic sources on the CyberLeni…
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
Relevance. The mechanisms of B-lymphocyte immunity are not fully understood at present, in particular, the role and significance of the humoral response to viruses. There is insufficient understanding of how B-lymphocytes are selected for differentiation into …
Objective. To analyze the potential risks and technological limitations of using genome editing methods in neurodegenerative diseases, as well as to assess the prospects for their implementation in clinical practice. Material and methods. A systematic analysis…
Introduction. Due to the rapidly growing incidence of tumor pathology of the thyroid gland, the range of molecular genetic research methods used to study the targets of targeted drugs, prognosis and surgical tactics is growing. Aim. To study the frequency of m…
Introduction. In general, the physiological response of tissues to external stresses is not linear in accordance with Hooke's law. Biological tissues are known to exhibit a nonlinear relationship between stress and strain, although the origins of this nonlinea…
Introduction. Bronchial asthma is an inflammatory disease manifested by various phenotypes. The most studied phenotype of asthma is allergic. Molecular allergodiagnostics of allergic diseases using microchips makes it possible to determine the molecular profil…
Introduction. Type 1 diabetes mellitus is a chronic autoimmune disease associated with severe complications of organs and systems, including complications of the course of dental diseases. Material and methods. Results of 55 patients with type 1 DM became the …
Introduction. Chronic heart failure is a multifactorial disease, an important role in the pathogenesis of which is played by disorders of the functions of mitochondria and energy metabolism in cardiomyocytes, as well as a significant contribution is made by ge…