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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 58–69

Polypragmasy in elderly and senile patients with chronic kidney disease: START/STOP criteria in elderly and senile patients taking DOAC

Introduction. Thanks to the achievements of modern medicine, it was possible to significantly increase the life expectancy of the population. Molecular mechanisms of aging include telomere shortening, DNA damage accumulation, mitochondrial dysfunction, leading…

10.29296/24999490-2025-05-07Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 10–20

Biochemical markers of inflammation in drug-resistant tuberculous meningitis (experimental study)

Introduction. The determination of inflammatory markers used to monitor the course of the disease and monitor the effectiveness of treatment. Goal. To evaluate biochemical markers of inflammation in cerebrospinal fluid (CSF) and blood serum in experimental men…

10.29296/24999490-2025-05-02Details ↗
ОБЗОР2025 · pp. 89–96

The Impact of Genetic Polymorphisms in Toll-like Receptor Genes on Interaction with Helicobacter pylori

The aim of the study. To describe the interaction between Helicobacter pylori and Toll-like receptors, and to outline the role of TLRs gene polymorphisms in the pathogenesis of this infection. Material and methods. An analysis of publications from 2000 to 2025…

10.29296/24999490-2025-05-10Details ↗
ОБЗОР2025 · pp. 55–63

Neurotoxic complications of cancer chemotherapy

Introduction. Neurotoxicity is a common complication of chemotherapy that negatively affects the quality of life of cancer patients. Damage to the nervous system affects both the peripheral nerves (peripheral neuropathy) and the central nervous system (chemo b…

10.29296/24999490-2025-04-09Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 3–9

Interaction in the PAMPs – mucosal barrier – cytokines system in children with obesity

Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations be…

10.29296/24999490-2025-04-01Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 16–23

ASSESSMENT OF C-REACTIVE PROTEIN, PRESEPSIN AND LIPOPOLYSACCHARIDE-BINDING PROTEIN LEVELS IN CARDIAC SURGERY PATIENTS WITH POSTOPERATIVE INFECTIOUS-INFLAMMATORY COMPLICATIONS

Introduction Postoperative infectious and inflammatory complications worsen the prognosis of patients, increase the duration of hospitalization and increase the cost of treatment, therefore, the search for markers to determine the degree of risk of their devel…

10.29296/24999490-2025-04-03Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 39–42

Рroliferotropic effect of peptides in liver organotypic tissue culture of different age rats

Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism. Purpose of study. Study of proliferotropic effect of short peptides and p…

10.29296/24999490-2025-04-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 43–48

Prognostic significance of CD68+ macrophages in autoimmune inflammation in experimental study

Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …

10.29296/24999490-2025-04-07Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 24–29

Using claudin-2 to mark mossy fibers in the mouse hippocampus

The purpose of the present study was to test the possibility of identifying hippocampal mossy fiber projections by staining mouse brain sections with antibodies to the claudin-2 protein. Material and methods: the subjects of the study were 9 male wild mice. Se…

10.29296/24999490-2025-04-04Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 30–38

Serotonin, 5-HIAA, and membrane serotonin transporter in blood as biomarkers of familial hypercholesterolemia in immature low-density lipoprotein receptor-deficient mice

Introduction. Cardiovascular diseases are the main cause of death and disability in the world population. Serotonin plays a significant role in the development and progression of atherosclerotic processes due to its two classical functions – platelet aggregati…

10.29296/24999490-2025-04-05Details ↗
ОБЗОР2025 · pp. 64–74

The Role of P2X7 Receptors in the Pathogenesis of Depression and Autism Spectrum Disorders

Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders. The purpose of this literature review was a systematic analysis of information in the modern…

10.29296/24999490-2025-04-10Details ↗

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