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Molecular Medicine
Introduction. Significance of chronic parodontitis is determined by not only of the degree of the prevalence rate, severity of the disease, but also by the low efficacy of the treatment and diagnosis at the early stage of disease. Nowadays there are not comple…
Introduction. Hypermethylation of CpG islands in tumor-suppressor genes are supposed to be a key mechanism of the development of the myelodysplastic syndrome (MDS) The aim of the study. To determine the association between methylation status of SOX7, p15INK4b,…
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…
Introduction. Proton pump inhibitors (PPI) are widely spread as antisecretory drugs for a treatment of acid diseases, such as the gastric ulcer. Most of the proton pump inhibitors are inactivated in the liver by cytochromes P450 2C19 (CYP2C19) to the form of i…
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
Introduction. Despite the continuous improvement of the surgical method of treatment of patients with non-small cell lung cancer (NSCLC), there is no noticeable tendency to improve survival data. This 5-year index does not exceed 15–25%. In this regard, it is …
Purpose. To study pharmacokinetic parameters in studies of a comparative bioavailability in combination with the assessment of homeostatic mechanisms of the regulation on the example of calcium. Methods. There were studied pharmacokinetic parameters of calcium…
The aim of the study is an investigation of the association between mutations A1744S of MYH7, 9928_9929insE of TTN, T171M of CACNA1C, A189T of JPH2, S434Y of VCL, H4552R of RYR2, Y1495X of SCN5A and the sudden cardiac death (SCD). Investigating mutations were …
Introduction. The clinical use of the antitumor drug etoposide is associated with many side effects, limiting its application in the clinical practice. One of the ways to reduce the toxicity and increase the effectiveness of the action of etoposide can be its …
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…