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Molecular Medicine
Introduction.The telomerase activity is a universal marker for 85% of malignant tumors. This allows us to develop modern highly sensitive and highly specific kits for the diagnosis of most malignant tumors, including early stages of the disease. Existing metho…
Epigenetics studies inherited mechanisms capable of modulating gene expression without altering the DNA nucleotide sequence. Until very recently, epigenetics included inherited mechanisms, such as DNA methylation and histone modification. As of today, a large …
One of the ways to restore the lost functions of the thyroid gland is the creation of its tissue engineering constructs. The creation of adequate tissue engineering constructs requires either cultures of functionally active thyrocytes capable of forming thyroi…
The aim of the study was to analyze two single nucleotide substitutions in the NOS2 (rs2779249, c-1290G>T, 5'-region) and NOS3 (rs2070744, c-813C>T, in tron 1) genes in psoriasis patients. Materials and methods. DNA samples from 88 psoriasis patients and 365 c…
Introduction. The aim of this study to determine carrier frequencies of polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between theadmin…
The aim of this work was to study the effect of methotrexate, glucocorticoids and nonsteroidal anti-inflammatory drugs on the plasma levels of nitric oxide metabolites, as well as the level of NOS2 gene transcripts in peripheral blood leukocytes (PBL) in rheum…
The use of dextran sodium sulphate (DSS) as an agent for the induction of the experimental colitis is regarded as a valid method in experimental biology and medicine for the estimation of the effectiveness of pharmacological preparations for the treatment of i…
Introduction. Mass genotyping, aimed both at identifying of genetic characteristics of populations and the creation of genomic libraries, scientific research, was implemented on large samples, required the accumulation and/or conservation of samples of the bio…
Telomerase catalytic subunit hTERT is tightly regulated both at the transcriptional and posttranscriptional levels. One of the regulatory mechanisms is its mRNA alternative splicing. Only full-length form has catalytic activity and the ability to elongate telo…
Introduction. The Alzheimer disease (AD) is the socially important neurodegenerative disease. The promising way of the early lifetime diagnosis of the AD is the investigation of the expression of signal molecules by cells in a cerebrospinal fluid, blood lympho…
Introduction. The study of molecular mechanisms of the development of kidney cancer is one of the actual problems in oncology. There is conflicting information about the importance of steroid hormone receptors in the kidney cancer. The aim of the study was to …
Introduction. Apolipoprotein-E (apoE), being one of the metabolically active apoproteins plays the important role in lipid metabolism. The aim of the study was to investigate the quantitative distribution of apoE between different lipoprotein classes in health…