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Molecular Medicine
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
Аim of the study was to evaluate the activity of receptors that control contraction (α2-adrenergic receptor, purine P2X1 and P2Y receptors, angiotensin AT1 receptor, TxA2 receptor) and relaxation of smooth myocytes (adenosine A2 receptor) during standard litho…
The creation by COVID-19 of methods for prophylactic of these complications as blood hypercoagulation, leading to thrombosis and polyorganic insufficiency, is an urgent task of modern biology and medicine. The aim of the study was to develop the simple methods…
Introduction. Stomach cancer in Russia occupies the 4th place among most frequent malignant neoplasms, after tumors of the lung, breast and colon. The search for new diagnostic and prognostic markers of this pathology is an urgent task of modern molecular onco…
Background. Protein 4-1BB (CD137) enhances the activity of T-cells, prevents their death, and promotes the production of cytokines, which makes it a powerful co-stimulating agent. Currently, the use of this glycoprotein is being studied in order to influence t…
Dipeptides are physiological products of protein degradation and informational molecules. Asp-Pro, Asp-Ala, Glu-Ala peptides have geroprotective, reparative properties. The aim of the work is to evaluate the effect of the Asp-Pro, Asp-Ala и Glu-Ala peptides on…
Introduction. Prostate cancer (PC) is by far the most commonly diagnosed malignant neoplasm of the urinary system. The pathogenesis and molecular mechanisms of prostate cancer remain incompletely understood. There are reports of the presence in the extracts of…
Introduction. The creation of peptide bioregulators that contribute to the preservation of the basic physiological functions of the body is an urgent task of modern biology and medicine. The aim of the study was to evaluate the effect of polypeptide complexes …
Introduction. Neuroprotection in traumatic brain injury is a promising area of therapy for cerebral disorders. Neuroprotective effect can be implemented by a action on variety molecular targets, a change in the activity of which leads to the elimination of pat…
Introduction. Lactic acid bacteria synthesize antimicrobial substances of various nature: acids, alcohols, diacetyl, reuterin, hydrogen peroxide, carbon dioxide, etc. The Food and Drug Administration (USA) and the European Food Safety Authority have recognized…