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Molecular Medicine

ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 29–34

INFLUENCE OF FIBROBLAST GROWTH FACTOR-2 ON THE ACTIVATION OF MOUSE HIPPOCAMPAL MICROGLIA IN A LIPOPOLYSACCHARIDE-INDUCED NEUROINFLAMMATION MODEL IN VITRO

Introduction. Activation of the pro-inflammatory phenotype of microglia may be one of the causes of chronic neuroinflammation and, as a result, can lead to pathological conditions of the brain. The use of neurotrophic factors, such as FGF2, may become one of t…

10.29296/10.29296/24999490-2024-02-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 60–64

EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM

Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions,…

10.29296/24999490-2024-02-10Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 54–59

COMPUTER PREDICTION OF PHARMACOLOGICAL ACTIVITY OF SOLANUM TUBEROSUM L. ALKALOIDS

The alkaloids solanine and chaconine were discovered in 1821. However, its did not find medical use due to toxicity. At present, modern research methods have revealed anti-cancer activity of the alcaloids. In this regard, the hypothesis of the presence of othe…

10.29296/24999490-2024-02-09Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 48–53

Genetic predictors of the risk of developing complications in the immediate postoperative period following combat trauma

Introduction. Paratraumatic eczema (PTE), being a type of microbial eczema, occurs after surgical interventions, chronic wound healing, accompanied by pronounced inflammatory changes with hyperemia, edema, exudation, soreness and itching. Genetic polymorphisms…

10.29296/24999490-2024-02-08Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 21–28

BIOLOGICAL MODEL OF LUNG CANCER COMBINATION AND TUBERCULOSIS: DEVELOPMENT FOR PRECLINICAL STUDY OF RATIONAL COMBINATIONS OF TARGETED ANTITUMOR AND ANTITUBERCULOSIS THERAPY

Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…

10.29296/24999490-2024-02-04Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 60–64

EVALUATION OF THE EFFECT OF NEUROPEPTIDES OF THE MELANOCORTIN FAMILY ON STRESS-ASSOCIATED CHANGES IN THE LEVEL OF CORTICOTROPIN-RELEASING HORMONE AND CORTICOSTERONE

Introduction. To date, the problem of studying the neuropeptide system of regulation of adaptive processes is relevant, since the stress reaction is a trigger for the occurrence of various diseases, in particular depression. Corticoliberin is considered as the…

10.29296/24999490-2024-01-08Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 51–59

Biomechanical properties of nasal tissues

Introduction. Plastic rhinosurgery and augmentation rhinoplasty are very relevant today. Especially in relation to patients with congenital saddle deformity of the nasal dorsum, as well as patients with iatrogenic disorders of the nose shape, which dramaticall…

10.29296/24999490-2024-01-07Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 43–51

Mitochondrial proteins as biomarkers of occupational disease risk of pilots and astronauts

Introduction. Mitochondrial dysfunction is an important pathogenic mechanism of neurodegeneration, characterized by a progressive structural and functional loss of neurons, leading to heterogeneous clinical and pathological manifestations with subsequent impai…

10.29296/24999490-2024-01-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 35–42

EFFECTIVENESS AND SAFETY OF CARBOPLATIN-CONTAINING ANTITUMOR THERAPY REGIMENS IN A MODEL OF COEXISTANCE OF LUNG CARCINOMA AND TUBERCULOSIS

Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …

10.29296/24999490-2024-01-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 29–34

Trace elements and the inflammatory process development: predictive possibilities

Introduction. Late diagnosis of inflammatory pathologies leads to increased risks of chronicization of the process, generalization, development of complications, and reduced effectiveness of therapy. Routine methods of clinical laboratory diagnostics often hav…

10.29296/24999490-2024-01-04Details ↗
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