ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ

SIRTUINS: PREDICTIVE MOLECULAR DIAGNOSIS OF ALZHEIMER’S DISEASE IN LONG-LIVER

Pukhalskaya А.E., Linkova N.S., Umnov R.S., Kozlov K.L., Kvetnoy I.M., Paltsev M.A.

The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…

MITOCHONDRIA – INTRACELLULAR TARGETS OF GEROPROTECTIVE EFFECT OF V007

Kvetnoy I.M., Mironova E.S., Krylova Y.S., Mylnikova A.A., Zubareva T.S., Leont’eva D.O., Polyakova V.O., Petrosyan M.A.

Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…

DECREASE IN ANG AND VEGF mRNA LEVELS DURING PROGRESSIVE ANGIOGENESISOF THE LIVER VENOUS SYSTEM OF WISTAR RATS IN EXPERIMENTAL CIRRHOSIS

Introduction. Currently, understanding the molecular mechanisms of pathological angiogenesis remains a fundamental problem in hepatology. The aim of this work was to find a relationship between the level of mRNA expression of the ang, vegf genes and angiogenes…

PURINERGIC REGULATION OF STONES ELIMINATION FROM THE UPPER PARTOF THE URETER DURING LITHOKINETIC THERAPY

Barinov E.F., Malinin Y.Yu., Grigoryan Kh.V.

The reasons for the low efficiency of the α1A-blockers using in the scheme of lithokinetic therapy (LCT) remain unclear. The aim of the study was to evaluate the activity of the purinergic P2X1 receptor in the blockade of the α1A-adrenergic receptor during LCT…

STUDYING OF P-, E-SELECTINS AND GLYCOPROTEIN LIGAND PSGL-1 LEVEL IN BLOOD SERUMOF PATIENTS WITH ATHEROSCLEROSIS OF THE ARTERIES OF LOWER LIMB

Korotkova N.V., Kalinin R.E., Suchkov I.A., Nikiforova L.V.,Ryabkov A.N.

Introduction. The study of intermoleculars interactions can contribute to the development of ideas about the violation of the endothelium,s adhesive function as one of the pathogenetic links in the development of peripheral artery diseases of atherosclerotic e…

AED PEPTIDE ACTIVATES GENE EXPRESSION AND DIFFERENTIATION PROTEINS SYNTHESISOF HUMAN SKIN FIBROBLASTS DURING REPLICATIVE AGING

Gutop E.O., Linkova N.S., Fridman N.V., Kozhevnikova E.O.,Polyakova V.O., Khavinson V.Kh.

The aim of this work is to study the effect of the AED peptide on fibroblast differentiation of human skin when aging in vitro. Methods. The study was conducted on DF-1 cell line (human dermal fibroblasts (mesenchymal stem cells)) isolated from the skin of the…

SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED

Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V.

The main reason for the severity of COVID-19 and the death of patients is the «cytokine storm» – a strong inflammatory response caused by SARS-CoV-2. Macrophages, immune cells that help eliminate pathogens and repair damaged tissues, play a key role in the exp…

A personalized approach to the treatment and prevention of diabetic foot: molecular mechanisms and the role of taxifolin

Seliverstov P.V., Zakrevsky V.V., Ivaniuk A.S., Kerimova А.М., Maltsev S.E., Tokarev K.M.

Aim. To substantiate the pathogenetic rationale for including aqueous solution of dihydroquercetin (taxifolin) in the comprehensive treatment of diabetic foot and to present the results of a case series on the application of this form in patients with trophic …

Quantitative indicators of TREC and KREC as predictors of the severity of acute respiratory infections in children

Ligskaya E.V., Eremeeva A.V., Kudlay D.A., Satyshev O.V., Gordukova M.A., Korsunsky A.A.

Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…

Levels of GFAP, Iba1, TNF-α, and caspase-3 in the cingulate cerebral cortex of mice after intraperitoneal lipopolysaccharide

Venediktov A.A., Kuzmin E.A., Pokidova K.S., Oganesyan D.M., Stepanian A.T., Boronikhina T.V., Piavchenko G.A., Kuznetsov S.L.

Introduction. Bacterial lipopolysaccharide (LPS) affects the structure and function of nervous tissue cells. The aim of the study: to explore the impact of intraperitoneal LPS given to mice on levels of such markers as glial fibrillar acidic protein (GFAP), ad…