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Molecular Medicine
The aim of the study – the development of translational models of the alcoholic cardiomyopathy in rats to search and study the action mechanism of new original drugs for the treatment of this pathology. Methods. The complex of echocardiographic, electrophysiol…
Introduction. Despite extensive researches, no molecular markers are currently available for predicting progression of squamous cell head and neck carcinoma. The paper presents results of pilot study of proteins in blood serum of healthy volunteers and patient…
Introduction. Cytochrome P-450 2C19 is the main isoenzyme responsible for the metabolism of proton pump inhibitors, the main group of drugs for treating stomach and duodenal ulcer. There are genetic differences that affect the activity of this enzyme: there ar…
Introduction. In interstitial lung diseases (ILD), characterized by inflammatory and fibrous processes, the intensification of angiogenesis also occurs. The aim of our research. Was the study of characteristics of expression angiogenic molecules (VEGF, ET1) in…
Introduction. Hormonal aspect in the pathogenesis of melanoma development is still poorly studied. Tumor transplantation to experimental animals allows to study the effect of malignant process on different systems and organs, detect the saturation of tumor and…
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
Introduction. Nuclear medicine imaging is widely used in oncology for the assessment of pathophysiologic changes occurring in a tumor. In this regard, the intensive study of diagnostic efficiency of the existing radiopharmaceuticals and the search for the new …
Introduction. Targeted gene delivery plays an exceptional role in the development of gene therapy. Peptide-based carriers are promising group of non-viral gene delivery vehicles due to biodegradability and easy structural and amino acid sequence modifications.…
Introduction. Most cases of gastric cancer (GC) occur sporadically. Until recently, diffuse hereditary gastric cancer associated with the CDH1 gene mutations was considered the only hereditary form (about 1–3% of all tumors of the stomach). However, a signific…
Introduction. Determination of the functional activity of the endometrium at the molecular-cellular level opens new perspectives for diagnosis and correction processes of accelerated aging and pathology of the female’s reproductive system. Objective – learning…