Table of contents
Articles
THE MECHANISM OF TOLERANCE OF THE ESTROGEN-INDEPENDENT BREAST CANCER CELLS TO HYPOXIA:THE ROLE OF SNAIL1 AND BETA-CATENIN, THE EPITHELIAL-MESENCHYMAL TRANSITION PROTEINS
The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …
EXPRESSION OF METALLOPROTEINASES 2 AND 3 IN GASTRIC CANCER WITH DIFFERENT IMMUNOPHENOTYPIC VARIANTS
The immunohistochemical expression of MMP-2 and MMP-3 in carcinomas of the stomach, differed by product MUC1, 2, 5AС, 6 and CD10 has been investigated. In mixed carcinomas immunophenotypic variant parameters of studied MMP expression were significantly higher …
CELLULAR RETINOIC ACID BINDING PROTEIN (CRABP I) EXPRESSIONAND CELL PROLIFERATION IN PANCREATIC NEUROENDOCRINE TUMORS
Protein expression of CRABP I (Сellular Retinoic Acid Binding Protein I) was investigated by immunohistochemical analysis in pancreatic neuroendocrine tumors. Relationship of CRABPI expression to clinical features, cell proliferation activity level and metasta…
DIFFUSE LARGE B-CELL LYMPHOMAPRESENTED AS BONE LESIONS.A STUDY OF 21 CASES AND REVIEW OF THE LITERATURE
Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both morphologically and prognostically it represents a diverse spectrum of disease. Non-Hodgkin lymphoma of bone comprises approximately 7% of malignant bone tumors, 5% of extranodal lymphom…
CLINICAL IMPLICATIONS OF TUMOR ASSOCIATED PROTEASES DETERMINATIONIN THE TUMORS AND BLOOD PLASMA OF COLORECTAL CANCER PATIENTS
Associations between matrix metalloproteinase (MMP) 2, 7, 9, tissue MMP inhibitor TIMP-1 and plasminogen activation system components (uPA, tPA and PAI-1) plasma and/or tumor levels in colorectal cancer (CRC) patients were evaluated in order to reveal their po…
IMMUNOGLOBULIN FREE LIGHT CHAINS – BIOCHEMICAL MARKERS OF MONOCLONAL GAMMOPATHIES
Serum κ- and λ- free light chains and their ratio were measured in 126 patients (23-80 years old) with monoclonal gammopathies and 60 normal individuals (25-82 years old). The free light chains (FLCs) assay was performed using the FreeliteTM test-system (The B…
ABNORMALITIES OF HEMOSTASIS AND THEIR PREVENTION IN CANCER PATIENTS
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
ASSOCIATIONS OF SINGLE NUCLEOTIDE POLYMORPHISMSWITH BONE TUMORS IN PATIENTS IN RUSSIAN POPULATION
Ethiology and pathogenesis of bone tumors presenting a rare group of oncological diseases, are not fully understood. We have studied 6 single nucleotide polymorphisms rs7921 (GH1), rs7956547(IGF1), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), rs169091…
CONFIRMATION OF FIELD CANCERIZATION IN THE GENESIS OF SUPERFICIAL BLADDER CANCER
The paper presents the results of our own investigation of abnormal methylation of tumor suppressor genes RASSF1A, P16, CDH1, LAMC3, DAPK in tumors and non-tumor tissues obtained from 64 patients with superficial bladder cancer. The purpose of the research is …
MALIGNANT SMALL ROUND CELL TUMORS OF EWING’S SARCOMA FAMILY:MODERN CONCEPTS OF HISTOGENESIS, IMMUNOHISTOCHEMICAL AND MOLECULAR MARKERS
Immunohistochemical and molecular biological characterization of Ewing’s sarcoma family tumors is proposed. Immunophenotypical heterogeneity is shown to be noted, besides genome defects found in tumours.
ANALYSIS OF GENETIC POLYMORPHISMS IN ESTROGENMETABOLIZING ENZYMES IN OVARIAN CANCER PATIENTS IN THE SIBERIA REGION
Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogene…
ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS IN OVARIAN CANCER
A literature review is devoted to the analysis of clinical significance of key factors of neoangiogenesis in ovarian cancer patients, their connection with the main clinical and morphological characteristics of the disease, prognosis, features an anti-angiogen…