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Molecular Medicine
Found: 433
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
Implantation is the key process for becoming pregnant. Failure of implantation in IVF cycles is one of the main problems of modern reproductology. Search for biomarkers and the determination of the best time and maximal endometrial receptivity for the implemen…
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …
Genomic and molecular genetic studies of autism can identify new biological markers to determine the etiology and the molecular and cellular mechanisms of the pathogenesis of this disease. In addition to the fundamental importance of this research the laborato…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Introduction. Matrix metalloproteinase (MMP) – a family of extracellular zinc-containing proteases. There are currently 25 known MMP. Increased activity of MMP observed in some physiological processes – during the follicular phase of the menstrual cycle and du…
Introduction.Transitional cell carcinoma of the bladder is the second most common malignancy of the genitourinary tract. Cystoscopy and urine cytology are the traditional most used techniques for diagnosis and surveillance of superficial bladder cancer. Urinec…
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Chemiluminescence is used to investigate the oxidative metabolism of blood cells for half a century. Numerous techniques for evaluation monocyte and neutrophil function have been developed. Applying of chemiluminescent analysis in clinical and experimental res…
Regulatory T-cells CD4+CD25+FoxP3+CD127low (Тregs) belong to the family of CD4+ T-cell subpopulation. Tregs display the suppressive activity and play a critical role in regulation and maintenance of autotolerance and immune homeostasis. The generation and diff…
Based on literature and own data the role of genotoxic events in nosogenesis of hereditary, congenital and somatic diseases is considered. Special emphasis is paid to the analysis of significance of premutagenic DNA lesions and as well induced gene mutations i…
The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in ather…
Salinomycin is referred to the group of the polyether antibiotics with ionophore activity. Currently salinomycin is considered as a potential anticancer drug. The aim of this work was to investigate the cytotoxic activity of salinomycin against MDR1+ (Mel-8) a…
The influence of the DNA minor groove binding ligands on epigenetic silencing in eukaryotic human cells has been demonstrated for the first time. Using HeLa cell population that harbors silent GFP-reporter gene under control of the CMV promoter we demonstrated…
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
The morphological and functional study of platelets stained with vital fluorochrome dyes has been performed in the blood of 100 donors and 100 hematological patients with thrombocytopenia. In hematologic patients with clinically pronounced hemorrhagic syndrome…
Immunohistochemical and molecular biological characterization of Ewing’s sarcoma family tumors is proposed. Immunophenotypical heterogeneity is shown to be noted, besides genome defects found in tumours.
To assess the detection and prognostic significance of donor-specific HLA antibodies serum samples from 66 recipients were examined. Donor-specific antibodies (DSA) have been identified in the sera of 15 patients (22,7%). To assess the effect on DSA during the…
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…