This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 99
Pathophysiology as a science and curriculum discipline stands in front of the biggest challenge in its history. It extended farbeyond the limits of its historical name and embedded aspects of Pathochemistry, Immunopathology, Pathobiophysics and Pathoinformatic…
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
Introduction. Diagnosis of genomic and chromosomal anomalies is based on the application of cytogenetic and molecular technologies. The aim of the study. The objective of the work was the delivery and the use of the algorythm for diagnosis of structural genomi…
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …
Introduction.Transitional cell carcinoma of the bladder is the second most common malignancy of the genitourinary tract. Cystoscopy and urine cytology are the traditional most used techniques for diagnosis and surveillance of superficial bladder cancer. Urinec…
Summary. Polymorphism of cytokine genes IL-2 (T330G), IL-10 (S819T) and IL10 (G1082A) in chronic viral hepatitis C. The analysis of the frequency of occurrence T330G polymorphism in the promoter region of the gene IL-2, S819T and G1082A promoter region of IL-1…
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the…
Staphylococcus aureus is a common human pathogen. In the past few decades, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become a global problem. MRSA is resistant to all β-lactam antibiotics, except anti-MRSA cephems, and is one…
To study the correlation of proliferative activity of tumor cells with clinical and morphological parameters and indices of survival rates a retrospective clinical and morphological analysis of 60 cases of localized and metastatic neuroendocrine tumors (NETs) …
Microfluidics can raise our sights in the biomedical area. This paper presents an overview of microfluidic systems (IFS), which is evidence of the urgency of this trend. The concept of development of the microfluidic system (MFS) and the technology of producti…
The Use of the technique of contrast enhancement in spiral computed tomography (SCT) allows us to study the peculiarities of hemodynamics in the tumor tissue and thus facilitates the differential diagnosis. Сomparison of SKT data with the results of morphologi…
Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and regulated as a function of their size, shape, surface chemistry and interior void space. Dendrimers are hyperbranched polymers with unique physical and chemical properties…
Pre-metastatic niche formation precedes tumor dissemination although the mechanisms of it remain unclear. Therefore, the aim of the study was to evaluate the expression of molecules characterizing the microenvironment remodeling in target organs lungs and live…
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…