This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 841
Argirophilic proteins of nucleolar organizer regions (Ag-NOR) pose a wide group of nucleolar proteins specifically stained by AgNO3. Expression level of Ag-NOR proteins in proliferating cells, including tumor ones, is commonly high. Nucleophosmin/B23 and nucle…
Buccal epithelium (BE) is an easily accessible target for molecular diagnosis of various diseases, and non-invasive way to get it is possible. This review summarizes the results of studies indicating a change in the expression of various signaling molecules an…
An approach to the development of methodology for health risk assessment (HRA) for the effects of new environmental factors: nanoparticles and nanobiomaterials (NP/NBM) – products of modern nano-, nanobiotechnology has been proposed. The experience from develo…
In recent years, scientists from different countries are actively discussing the concept of translational medicine and consider it as important area of molecular medicine development. Translational medicine promotes the transfer of discoveries made in basic bi…
There is a growing body of evidence confirming the validity of the concept of cancer stem cells (CSCs). It is becoming increasingly obvious that CSCs, possessing higher tumorigenicity, metastasis-initiating activity and chemoresistance, are a source of tumor g…
In present study, we investigated the proteasome and calpain activities in patients with endometrial hyperplasia (EH) and endometrial cancer (EC), as well as proteasome subunit composition in EC tissue. EC development was shown to be associated with increased …
The role of aromatase P450 in the pathogenesis of external genital endometriosis (IEG) has been investigated. 45 women with endometriosis have been included in the study, the group of comparison was consisted of 9 healthy women. The examination included a lapa…
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
Sertoli cells are the primary cells that support developing spermatogenic cells in the seminiferous tubules. Heat treatment induces a reversible change in the Sertoli cells (SC) from the mature differentiated state to an immature-like dedifferentiated state. W…
This review is devoted to availability of investigation of expression of signaling molecules in personalized and predictive medicine. As exemplified in cardio-vascular pathology (hypertonic disease, myocardial infarction), Alzheimer’s disease and chronic obstr…
reduced levels of monocytic TF expression in comparison with homozygous ones (160,1±53,0% and 198,6±72,9% M±SD, accordingly). If compared with homozygous allelic variants D-1208I heterozygous genotype is associated with less macrophagic TF expression in lungs …
Microfluidics can raise our sights in the biomedical area. This paper presents an overview of microfluidic systems (IFS), which is evidence of the urgency of this trend. The concept of development of the microfluidic system (MFS) and the technology of producti…
The association of +/– polymorphic markers of GSTM1 and GSTT1 genes and Ile105Val polymorphic marker of GSTP1 gene with the risk of development of breast cancer (BC) and its histological subtypes was studied. We have showed an association of null genotypes of …
The dependence of biochemical markers of bone resorption (C-terminal telopeptide of type I collagen – b-CTx, deoxypyridinoline – DPID, tartrate-resistant acid phosphatase (TRAP) 5b) and osteosynthesis (bone alkaline phosphatase – BALP) on clinical manifestatio…
The review discusses the biosafety issues related to the rapid development of molecular medicine and biotechnology. On an example of the USA data on efficiency of the accepted legislative base on restriction of dual use technologies, and also efficiency of the…
The Use of the technique of contrast enhancement in spiral computed tomography (SCT) allows us to study the peculiarities of hemodynamics in the tumor tissue and thus facilitates the differential diagnosis. Сomparison of SKT data with the results of morphologi…
The work is devoted to the study of the expression of the signaling molecules involved in apoptosis, proliferation, extracellular matrix remodeling and the formation of immune status of the pineal and thymus glands. In the pineal and thymus glands in people ov…
Immunohystochemical examination revealed increasing of GLUT1 and decreasing of GLUT3 expression through gestation. In cases with missed abortion higher expression of GLUT1 and lower expression of GLUT3 in comparison with their expression in control group are c…
The assessment of vascular endothelial growth factor (VEGF) and endotelial NO – synthase (eNOS) expression levels in placental tissue samples obtained from pregnant females with gestational diabetes mellitus (GDM) has been performed. The highest level of these…
In a series of laboratory experiments on the surface of dentin treated with etching gel – 38% Phosphoric Acid, and exposed to 95% ethanol solution for 30 days at ambient temperature the crystal structures have been found. Three-Dimensional Visualization of the…