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Molecular Medicine
Found: 21
Introduction. This review is devoted to the problem of the pathogenesis of pain syndrome in multiple myeloma (MM). The severity of pain often correlates poorly with the plasma cell burden but is highly dependent on tumor aggressiveness determined by primary ge…
Introduction. Male infertility is a complex medical problem affecting a significant part of the male population. According to the WHO, about 15% of couples worldwide face infertility problems, and in 40-50% of cases the cause is attributed to the male factor. …
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
Introduction. Studying the effect of the nitric oxide (II) donor, S-nitrosoglutathione, on the relative amount of selectin P in HUVEC cell lysates in vitro may contribute to fundamental understanding of the effect of the nitric oxide system on the adhesive fun…
Introduction. Tuberculosis is a socially significant disease, which is based on chronic granulomatous inflammation with the formation of fibrosis. The signaling molecules CD44 and ICAM-1 play an important role in the process of migration of immune cells from t…
Introduction. The study of intermoleculars interactions can contribute to the development of ideas about the violation of the endothelium,s adhesive function as one of the pathogenetic links in the development of peripheral artery diseases of atherosclerotic e…
Communities of microorganisms are a set of species that interact with each other and occupy the same niche where competitive or mutually beneficial relationships can occur. Biofilms are only one of many types of microbial communities, the study of which has be…
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provi…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
Introduction. Producing of combined biotransplants with human platelets may be accompanied by high rate of the loss of biological active platelet components. It is suggested to use blockers of platelet activity to fix these cells on adhesive substrate surface.…
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…
Introduction. Modulation of cellular adhesion of the retinal pigment epithelium (RPE) is a highly promising therapeutic approach for different eye diseases. As inflammation plays the crucial role in ocular diseases the impact of prostaglandins and proteases on…
In the literature review there are presented the modern views on the concept of the pathogenesis of Crohn’s disease (CD). There has been analyzed the role of defects in innate immunity in CD associated with mutations in genes NOD2/CARD15, ATG16L1, IRGM which r…
Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…
The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in ather…