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Molecular Medicine
Serum κ- and λ- free light chains and their ratio were measured in 126 patients (23-80 years old) with monoclonal gammopathies and 60 normal individuals (25-82 years old). The free light chains (FLCs) assay was performed using the FreeliteTM test-system (The B…
Retrospective analysis of data of histological and ultrasound examination of 199 fragments of arterial wall of internal carotid artery obtained during reconstructive operations was conducted. A retrospective analysis of ultrasound data and histological examina…
A recent literature review presents main approaches of cell fluorescence study in various fields of biology and medicine, including molecular medicine, problems of vital stained cell analysis and the prospect of fluorescent microscopy application.
Ductal adenocarcinoma is the most common type of pancreatic tumors that is notable for its highly aggressive phenotype, difficulties in diagnosis establishing, exceptionally unfavorable prognosis and resistance to standard methods of therapy . The development …
Publications devoted to the role of various representatives of matrix metalloproteinases (MMPs) family and their tissue inhibitors in ovarian cancer in differential diagnostics, prognosis and in the development of new treatment modalities are critically analyz…
Preclinical experimental study of toxic and allergenic properties of new pharmaceutical composition of diindolylmethane was carried on in various doses. It was established that tested drug refers to toxicity class V (almost non-toxic pharmaceutical substance) …
Last successful results in target therapy of cancer were achieved with different tyrosine kinases inhibitors (TKI). Target therapy of non-small cell lung cancer (NSCLC) with EGFR inhibitors gefitinib and erlotinib is effective only in patients with somatic mut…
The review is devoted to the role of some signaling molecules produced by neuroendocrine and immune cells of the gastrointestinal tract (GIT) in the pathogenesis of the diseases of the digestive system. Special attention is paid to the key signaling molecules …
Staphylococcus aureus is a common human pathogen. In the past few decades, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become a global problem. MRSA is resistant to all β-lactam antibiotics, except anti-MRSA cephems, and is one…
There are many applications of biosensors in biochemical analysis. High specifity of biorecognizing element that allows to carry out a quantitative analysis of complex analytes with high accuracy and to detect ultrasmall concentration of the certain molecules …
Based on literature data and analysis of own observation the hypothesis of pathogenesis of diffuse parenchymal lung osteodystrophy (DPLOD) is proposed. DPLOD is a very rare disease with unknown etiology. It is characterized by unilateral or bilateral lesions o…
To study the correlation of proliferative activity of tumor cells with clinical and morphological parameters and indices of survival rates a retrospective clinical and morphological analysis of 60 cases of localized and metastatic neuroendocrine tumors (NETs) …