This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
In the paper there are presented results of the study of the mechanisms of accumulation of the radiocolloid preparation in white blood cells. The study included an assessment of the effect of conditions of blood sampling (the diameter of the needle) and incuba…
Assessment of the effectiveness of thrombolytic and anticoagulation therapies was performed in 92 patients with pulmonary tromboembolism (PTE), aged from 22 to 88 years (average age is 59,3±13,9 years). In accordance with the diagnostics algorithm of PTE, acce…
With the purpose to determine the content of apoptotic lymphocytes of venous blood in norm and pathology there were examined 40 primary donors of blood, 14 patients with closed abdominal trauma complicated by acute blood loss of at least 30% of circulating blo…
Electrochemical method of antioxidants level determination in biological media was developed. The comparison of the blood serum redox potential and antioxidant activity for practically health people (n=31) was carried out. The effect of added antioxidants and …
The study data of the epidermal growth factor receptors(EGFR), estrogen and progesterone receptors(ER, PR) in the endometrial tumors in 125 patients are presented. EGFR have been detected in 40% of tumors. The EGFR–RP+ER+ tumors were detected most frequently (…
This review is devoted to availability of investigation of expression of signaling molecules in personalized and predictive medicine. As exemplified in cardio-vascular pathology (hypertonic disease, myocardial infarction), Alzheimer’s disease and chronic obstr…
Chemiluminescence is used to investigate the oxidative metabolism of blood cells for half a century. Numerous techniques for evaluation monocyte and neutrophil function have been developed. Applying of chemiluminescent analysis in clinical and experimental res…
Pathophysiology as a science and curriculum discipline stands in front of the biggest challenge in its history. It extended farbeyond the limits of its historical name and embedded aspects of Pathochemistry, Immunopathology, Pathobiophysics and Pathoinformatic…
Education in medicine has been facing a challenging problem of relations between basic biomedical sciences and clinical medicine. In postgenomic era emerging didactic issue is related both to contents and quantity of knowledge to be studied. Qualitative and qu…
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
Introduction. Diagnosis of genomic and chromosomal anomalies is based on the application of cytogenetic and molecular technologies. The aim of the study. The objective of the work was the delivery and the use of the algorythm for diagnosis of structural genomi…