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Molecular Medicine
Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and…
Leiomyoma is one of the most common benign tumors of the female reproductive system. As this pathology in most cases is hormone dependent, we determined the level of gene expression of steroid receptors ERs, PR, estrogen sulfotransferase SULT1E1, STS steroid s…
aryngeal and laryngopharyngeal cancer response to neoadjuvant chemotherapy as well as to investigate the feasibility of 199Tl-chloride for visualization of primary and recurrent laryngeal tumors. Materials and Methods: The study included 60 patients with stage…
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the…
Associations between matrix metalloproteinase (MMP) 2, 7, 9, tissue MMP inhibitor TIMP-1 and plasminogen activation system components (uPA, tPA and PAI-1) plasma and/or tumor levels in colorectal cancer (CRC) patients were evaluated in order to reveal their po…
Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both morphologically and prognostically it represents a diverse spectrum of disease. Non-Hodgkin lymphoma of bone comprises approximately 7% of malignant bone tumors, 5% of extranodal lymphom…
Protein expression of CRABP I (Сellular Retinoic Acid Binding Protein I) was investigated by immunohistochemical analysis in pancreatic neuroendocrine tumors. Relationship of CRABPI expression to clinical features, cell proliferation activity level and metasta…
The immunohistochemical expression of MMP-2 and MMP-3 in carcinomas of the stomach, differed by product MUC1, 2, 5AС, 6 and CD10 has been investigated. In mixed carcinomas immunophenotypic variant parameters of studied MMP expression were significantly higher …
The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …
Introduction. Breast cancer pathogenesis is associated with alterations in processes of regulating of IGF effects and also in IGF-signaling pathway activation. The direct correlation between high IGF blood serum levels and the rescue of malignancies in prostat…
Introduction. Insulin-like growth factors (IGFs) signaling system plays a key role in development and progression of various malignant tumors, and its components may be considered as prospective diagnostic and prognostic markers and potential objects of target…
Introduction. Due to the impetuous development of endovideosurgery in gynecology, laparoscopic access technique is increasingly frequently used to perform myomectomy. However in the available literature until now there is no decisive opinion on the feasibility…